Disease Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Adenocarcinoma
CUI: C0001418
Disease: Adenocarcinoma
0.090 GeneticVariation BEFREE Squamous Cell Carcinoma "Transformation" Concurrent with Secondary T790M Mutation in Resistant EGFR-Mutated Adenocarcinomas. 26746366 2017
Adenocarcinoma
CUI: C0001418
Disease: Adenocarcinoma
0.090 GeneticVariation BEFREE Both sporadic and germline T790M mutations were predominantly adenocarcinomas, favored female gender, and were occasionally multifocal. 24736066 2015
Adenocarcinoma
CUI: C0001418
Disease: Adenocarcinoma
0.090 GeneticVariation BEFREE Exon 20 T790M point mutation (T790M) was detected in 3 squamous carcinomas and 3 adenocarcinomas and exon 20 insertion mutation (20-ins) was detected in 2 patients with adenocarcinoma. 24351833 2014
Adenocarcinoma
CUI: C0001418
Disease: Adenocarcinoma
0.090 GeneticVariation BEFREE Three metastatic/recurrent adenocarcinomas demonstrated an additional EGFR T790M mutation that was not identified in the original specimens. 23495083 2013
Adenocarcinoma
CUI: C0001418
Disease: Adenocarcinoma
0.090 GeneticVariation BEFREE A lung biopsy from the left lower lobe disclosed an adenocarcinoma which harbored an in-frame deletion in exon 19 (heterozygous delE746-A750) of EGFR without a second mutation such as T790M in exon 20. 17618013 2008
Adenocarcinoma
CUI: C0001418
Disease: Adenocarcinoma
0.090 GeneticVariation BEFREE A gefitinib-resistant point mutation (T790M) in exon 20 without gefitinib treatment was detected in 1 AAH and 1 adenocarcinoma. 17561305 2008
Adenocarcinoma
CUI: C0001418
Disease: Adenocarcinoma
0.090 GeneticVariation BEFREE In human lung adenocarcinomas harboring EGFR mutations, a second-site point mutation that substitutes methionine for threonine at position 790 (T790M) is associated with approximately half of cases of acquired resistance to the EGFR kinase inhibitors, gefitinib and erlotinib. 18093943 2008
Adenocarcinoma
CUI: C0001418
Disease: Adenocarcinoma
0.090 GeneticVariation BEFREE Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors. 17085664 2007
Adenocarcinoma
CUI: C0001418
Disease: Adenocarcinoma
0.090 GeneticVariation BEFREE We also identified the TKI drug resistance-associated EGFR T790M mutation in an untreated case of Barrett's esophagus and the corresponding adenocarcinoma. 16857803 2007