|
Cervix carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the present study, we have examined a large study population to determine whether the C677T polymorphism at the MTHFR locus affects susceptibility for cervical cancer or its precursor, cervical intraepithelial neoplasia (CIN).
|
15635481 |
2005 |
|
Malignant neoplasm of colon and/or rectum
|
|
0.100 |
GeneticVariation
|
BEFREE |
To study the relation between genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) C677T or A1298C and the susceptibility of colorectal cancer.
|
18712959 |
2009 |
|
Vascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found raised median tHcy levels in all patient groups vs. controls (p < 0.05), with odds ratios (95% CI) for vascular disease among patients with HHcy (defined as > 15 micromol/l) of 3.9 (0.6 - 14.3), 4.8 (1.2 - 18.8) and 15.8 (2.8 - 87.3) respectively. tHcy levels were a function of MTHFR C677T genotype, and all patients with tHcy levels > 30 micromol/l had the MTHFR C677T homozygous substitution.
|
14698652 |
2003 |
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
To evaluate the genetic polymorphism of MTHFR C677T among β-TM patients and its prospective contribution to Hhcy and related oxidative changes.
|
27187171 |
2016 |
|
Prostate carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The MTHFR C677T polymorphism and prostate cancer risk: new findings from a meta-analysis of 7306 cases and 8062 controls.
|
22938427 |
2012 |
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data fail to support a relationship between MTHFR C677T and the risk for breast cancer.
|
16134079 |
2007 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
This may be associated with the T/T genotype in the MTHFR gene; however, the distribution of the MTHRF C677T polymorphism in the Polish population does not differ in AD and controls.
|
12784029 |
2003 |
|
Complete Trisomy 21 Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
The pooled OR was estimated under five genetic models and significant association was found between maternal MTHFR 677C>T polymorphism and Down syndrome under four genetic models except recessive model (for T vs. C, OR = 1.26, 95% CI = 1.09-1.46, p = 0.001; for TT vs. CC, OR = 1.49, 95% CI = 1.13-1.97, p = 0.008; for CT vs. CC, OR = 1.29, 95% CI = 1.10-1.51, p = 0.001; for TT+CT vs. CC, OR = 1.35, 95% CI = 1.13-1.60, p = 0.0008; for TT vs. CT+CC, OR = 0.76, 95% CI = 0.60-0.94, p = 0.01).
|
25265565 |
2014 |
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Common C677T polymorphism in the methylenetetrahydrofolate reductase gene increases the risk for deep vein thrombosis in patients with predisposition of thrombophilia.
|
10706928 |
2000 |
|
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
Homozygosity for the thermolabile variant of 5,10-methylene tetrahydrofolate reductase (C677T) has been suggested to be positively associated with the risk of vascular disease and neural tube defects.
|
17010581 |
2007 |
|
Folic Acid Deficiency
|
|
0.100 |
GeneticVariation
|
BEFREE |
This computational model shows that de novo dTMP synthesis is highly sensitive to the common MTHFR C677T polymorphism and that the effect of the polymorphism on FOCM is greater in folate deficiency.
|
28400561 |
2017 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the prevalence of MTHFR C677T and prothrombin G20210A genotypes by polymerase chain reaction (PCR) followed by restriction enzyme digestion in 420 Chinese subjects: 53 with deep venous thrombosis (DVT); 145 with cerebrovascular disease [115 cerebral infarction, 30 cerebral haemorrhage (CH)]; 100 with coronary artery disease (CAD); and 122 control subjects.
|
10929044 |
2000 |
|
Adenoma of large intestine
|
|
0.100 |
GeneticVariation
|
BEFREE |
No evidence of association of C677T (4,616 patients and 6,338 controls) and A1298C (1,272 patients and 1,684 controls) with colorectal adenoma were found.
|
17089070 |
2007 |
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In summary, during this meta-analysis, we found that MTHFR C677T polymorphism was significantly associated with breast cancer risk in the Chinese population.
|
24078451 |
2014 |
|
Male infertility
|
|
0.100 |
GeneticVariation
|
BEFREE |
Methylenetetrahydrofolate reductase gene (MTHFR C677T and A1298C) and methionine synthase gene (MS A2756G) polymorphisms have shown an association with male infertility risk in several ethnic populations.
|
28081209 |
2017 |
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We have analyzed the MTHFR C677T polymorphism in 52 patients and 88 control individuals, all ethnic Greek residents of northern Greece, and examined the association of this polymorphism with (a) susceptibility to childhood ALL and (b) the distribution of average plasma alanine aminotransferase (ALT) levels, white blood cell counts (WBC), and hemoglobin levels (Hb) during the induction and consolidation phases of treatment.
|
16123993 |
2006 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
To investigate the modifying effects of two candidate genes (serotonin transporter gene linked promoter region (5-HTTLPR) and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms) on the associations between general somatic morbidity and incidence of depression in an East Asian population with high frequencies of potential risk alleles.
|
19251870 |
2009 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The merits of two techniques, molecular beacon and amplification effect of enzymatic color, are successfully combined, and the technique is simple, sensitive and specific, to detect and compare the methylenetetrahydrofolate reductase (MTHFR) Gene C677T mutation of subjects between coronary heart disease (CHD) and control group.
|
21802936 |
2011 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
DNA was extracted from the whole blood of 192 natural postmenopausal women (40 to 65 years) screened for the METS and tested for three gene SNPs related to obesity: the fat mass obesity (FTO: rs9939609) and the methylenetetrahydrofolate reductase (MTHFR: C677T and A1298C).
|
26902996 |
2016 |
|
Esophageal Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conducted a meta-analysis to investigate the association of MTHFR C677T and folate intake with esophageal cancer risk.
|
23534726 |
2013 |
|
Stomach Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The MTHFR C677T frequencies of CC, CT, and TT genotypes were 35.2%, 47.5%, and 17.3% among stomach cancer, 34%, 50.5%, and 15.5% in colorectal cancer, and 31.8%, 50.7%, and 17.5% in the controls, respectively.
|
20504332 |
2010 |
|
Migraine Disorders
|
|
0.100 |
GeneticVariation
|
BEFREE |
In adult studies the MTHFR C677T polymorphism has been associated with an increased risk of migraine, but little research has been done in this area in children.
|
30170616 |
2018 |
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The thermolabile variant of methylene-tetrahydrofolate reductase (MTHFR), c.677C>T, is one of the most common genetic condition, which has been associated with mild to moderate hyperhomocysteinemia, and carriers of this variant are at increased risk of an early-onset stroke-like episode.
|
23526309 |
2013 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
To observe the association of MTHFR gene C677T locus polymorphism with occurrence of congenital heart defects (CHDs), 21 patients with atrial septal defect (ASD), 35 patients with patent ductus arteriosus (PDA), one patient with both conditions combined, and their biological parents were collected as the case group.
|
16373366 |
2006 |
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
Additionally, more high-quality studies and that the covariates responsible for heterogeneity should be controlled to obtain a more conclusive response about the function of MTHFR C677T in cancer.
|
24744129 |
2014 |