|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
Elevated Hcy levels in the presence of the T allele in the C677T gene and of the A allele in the A1298C gene are associated with AMI and massive and submassive PE.
|
29916259 |
2019 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
Moreover, C677T polymorphism had a protective effect against MI r</span>isk under the dominant model (OR=0.93, 945%CI=0.87-0.99, fixed effects) in elderly (≥50) population.
|
27179899 |
2016 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
Of the chosen polymorphisms, two (Leu125Val PECAM1 and A1/A2 FVII) are related to myocardial infarction and two (C677T MTHFR and 5A/6A MMP3) to advanced stenosis in arterial vessels (> 75%).
|
23274712 |
2013 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
Myocardial infarction in a newborn heterozygous for the MTHFR C677T mutation.
|
22339112 |
2012 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR C677T polymorphism and its relationship to myocardial infarction in the Eastern Black Sea region of Turkey.
|
22222489 |
2011 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
Meta-analysis results suggest that the MTHFR C677T polymorphism was associated with risk of MI in young/middle-aged Caucasians.
|
22154679 |
2011 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
We report a case of myocardial infarction at a young age in a subject heterozygous for the G20210A prothrombin gene variant and homozygous for the C677T MTHFR polymorphism, who presented a strong family history of atherothrombosis.
|
17920139 |
2008 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
Role of methylenetetrahydrofolate reductase 677C->T polymorphism in the development of premature myocardial infarction.
|
18255072 |
2008 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further, in contrast to reports from other investigators, we found little evidence for association of a C677T polymorphism in the 5,10-methylenetetrahydrofolate reductase gene, the angiotensin-I-converting enzyme 1 insertion/deletion polymorphism, a 4G/5G polymorphism in the serine/cysteine proteinase inhibitor-clade E-member 1 gene, the factor V Leiden mutation, the G20210A factor II mutation, a -455G>A polymorphism in the beta-fibrinogen gene, the cys112arg/arg158cys apolipoprotein E gene polymorphism, a gly460trp polymorphism in the alpha-adducin gene, and a -629C>A polymorphism in the cholesteryl ester transfer protein gene with risk of MI.
|
16420563 |
2006 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
Multivariable logistic regression analysis with adjustment for age, sex, body mass index, and the prevalence of smoking, hypertension, diabetes mellitus, and hypercholesterolemia revealed that the 677C-->T (Ala222Val) polymorphism of MTHFR, the 1595C-->G (Ser447Stop) polymorphism of LPL, and the -108/3G-->4G polymorphism of IPF1 were significantly associated with the prevalence of myocardial infarction.
|
16894468 |
2006 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
Prevalence of myocardial infarction is related to hyperhomocysteinemia but not influenced by C677T methylenetetrahydrofolate reductase and A2756G methionine synthase polymorphisms in diabetic and non-diabetic subjects.
|
15820491 |
2005 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
Case-control and prospective studies of association between MTHFR 677C-->T variant and myocardial infarction, coronary artery occlusion, or both; 80 studies were included.
|
16216822 |
2005 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
Folate, homocysteine levels, methylenetetrahydrofolate reductase (MTHFR) 677C --> T variant, and the risk of myocardial infarction in young women: effect of female hormones on homocysteine levels.
|
14717963 |
2004 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
We performed a MEDLINE search to identify published case-control and cohort studies correlating the factor V Leiden, prothrombin (PT) G20210A, and methylenetetrahydrofolate reductase (MTHFR) C677T (TT genotype) mutations with myocardial infarction, ischemic stroke, or peripheral vascular disease.
|
14660985 |
2003 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
None of the 9 polymorphisms of genes encoding proteins involved in coagulation (G-455A beta-fibrinogen: OR, 1.0; CI, 0.8 to 1.2; G1691A factor V: OR, 1.1; CI, 0.6 to 2.1; G20210A factor II: OR, 1.0; CI, 0.5 to 1.9; and G10976A factor VII: OR, 1.0; CI, 0.8 to 1.3), platelet function (C807T glycoprotein Ia: OR, 1.1; CI, 0.9 to 1.3; and C1565T glycoprotein IIIa: OR, 0.9; CI, 0.8 to 1.2), fibrinolysis (G185T factor XIII: OR, 1.2; CI, 0.9 to 1.6; and 4G/5G plasminogen activator inhibitor type 1: OR, 0.9; CI, 0.7 to 1.2), or homocysteine metabolism (C677T methylenetetrahydrofolate reductase: OR, 0.9; CI, 0.8 to 1.1) were associated with an increased or decreased risk of myocardial infarction.
|
12615788 |
2003 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings suggest that C677T transition in the MTHFR gene may be a risk factor for premature MI in Turkish men.
|
11303694 |
2001 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
We sought to investigate the association between the methylenetetrahydrofolate reductase (MTHFR) gene C677T mutation and the risk of coronary artery disease (CAD), myocardial infarction (MI) and venous thrombosis (VT) in a Chinese population in Taiwan.
|
11096270 |
2001 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
The T allele of MTHFR C677T yields an OR of 0.93 for IS (95% CI 0.62-1.39) and 0.77 for MI (95% CI 0.50-1.21).
|
11672761 |
2001 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
Several recent studies evaluated a possible effect of the prothrombotic polymorphisms such as 5,10 methylenetetrahydrofolate reductase (MTHFR) nt 677C --> T, factor V (F V) nt 1691G --> A (F V Leiden), and factor II (F II) nt 20210 G --> A on the risk of myocardial infarction.
|
10090925 |
1999 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
To investigate the association between the risk of myocardial infarction at a young age and genetic factors thought to be associated with an increased tendency to thrombosis (the polymorphisms 4G/5G of the PAI-1 gene, PIA1/PIA2 of the platelet glycoprotein IIIa, C3550T of the platelet glycoprotein Ib gene, G10976A of the factor VII gene, C677T of the methylenetetrahydrofolate reductase gene, G1691A of the factor V gene, and G20210A of the prothrombin gene), we performed a case-control study evaluating 200 survivors (185 men, 15 women) of myocardial infarction who had experienced the event before the age of 45 years and 200 healthy subjects with a negative exercise test, individually matched for sex, age, and geographic origin with the cases.
|
10381497 |
1999 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
The MTHFR C677T gene polymorphism was not associated with non-fatal myocardial infarction.
|
10337543 |
1999 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
Patients with angiographic evidence of CAD or clinical MI do not show an increased frequency of the C677T transition in the MTHFR gene.
|
9350916 |
1997 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data show that homozygosity for the C677T mutation in this largely white, middle-class US population is not associated with increased risk for MI, irrespective of folate intake.
|
8873653 |
1996 |