rs1217691063, MTHFR

N. diseases: 614
Disease: Sporadic Breast Carcinoma ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Sporadic Breast Carcinoma
CUI: C1336076
Disease: Sporadic Breast Carcinoma
0.020 GeneticVariation BEFREE The MTHFR C677T and A1298C polymorphisms do not alter the risk of BC, but are associated with the clinical severity of BC. 28330681 2017
Sporadic Breast Carcinoma
CUI: C1336076
Disease: Sporadic Breast Carcinoma
0.020 GeneticVariation BEFREE Reduced folate carrier 1 (RFC1) G80A and methylenetetrahydrofolate reductase (MTHFR) C677T were associated with risks of 1.34 (95% CI 1.01-1.79)- and 1.84 (95% CI 1.14-3.00)-folds, respectively, for sporadic breast cancer while cytosolic serine hydroxymethyl transferase (cSHMT) C1420T was associated with reduced risk (OR 0.71, 95% CI 0.53-0.94). 21113649 2011