Atrial Fibrillation
|
|
0.020 |
GeneticVariation
|
BEFREE |
Domestic pigs received AdKCNH2-G628S by epicardial atrial gene painting and atrial pacemaker implantation for continuous-burst pacing to induce atrial fibrillation.
|
28676183 |
2017 |
Atrial Fibrillation
|
|
0.020 |
GeneticVariation
|
BEFREE |
Gene therapy with KCNH2-G628S eliminated AF by prolonging atrial action potential duration.
|
20479154 |
2010 |
Cardiac Arrhythmia
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this review, we present a model of postinfarct ventricular tachycardia, a method for gene delivery to this area, and results of KCNH2-G628S gene transfer to manipulate cellular refractory properties in the arrhythmia model.
|
17993320 |
2008 |
Long QT Syndrome
|
|
0.710 |
CausalMutation
|
CLINVAR |
Phylogenetic and physicochemical analyses enhance the classification of rare nonsynonymous single nucleotide variants in type 1 and 2 long-QT syndrome.
|
22949429 |
2012 |
Long QT Syndrome
|
|
0.710 |
CausalMutation
|
CLINVAR |
Long QT syndrome in neonates: conduction disorders associated with HERG mutations and sinus bradycardia with KCNQ1 mutations.
|
14998624 |
2004 |
Long QT Syndrome
|
|
0.710 |
CausalMutation
|
CLINVAR |
A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome.
|
7889573 |
1995 |
Long QT Syndrome
|
|
0.710 |
CausalMutation
|
CLINVAR |
An in vivo cardiac assay to determine the functional consequences of putative long QT syndrome mutations.
|
23303164 |
2013 |
Long QT Syndrome
|
|
0.710 |
CausalMutation
|
CLINVAR |
HERG channel dysfunction in human long QT syndrome. Intracellular transport and functional defects.
|
9694858 |
1998 |
Long QT Syndrome
|
|
0.710 |
CausalMutation
|
CLINVAR |
Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia.
|
8700910 |
1996 |
Long QT Syndrome
|
|
0.710 |
GeneticVariation
|
BEFREE |
Isoform-specific dominant-negative effects associated with hERG1 G628S mutation in long QT syndrome.
|
22876326 |
2012 |
Long QT Syndrome
|
|
0.710 |
CausalMutation
|
CLINVAR |
Spectrum of pathogenic mutations and associated polymorphisms in a cohort of 44 unrelated patients with long QT syndrome.
|
16922724 |
2006 |
Long QT Syndrome
|
|
0.710 |
CausalMutation
|
CLINVAR |
Genotype-specific onset of arrhythmias in congenital long-QT syndrome: possible therapy implications.
|
17088455 |
2006 |
Long Qt Syndrome 2
|
|
0.820 |
GeneticVariation
|
BEFREE |
In female transgenic LQT2 rabbits (HERG-G628S, loss of IKr), hormone effects on QT/action potential duration (APD) were assessed (0.2-200 ng/L).
|
30938413 |
2019 |
Long Qt Syndrome 2
|
|
0.820 |
GeneticVariation
|
UNIPROT |
Four novel KVLQT1 and four novel HERG mutations in familial long-QT syndrome.
|
9024139 |
1997 |
Long Qt Syndrome 2
|
|
0.820 |
GeneticVariation
|
UNIPROT |
Mechanisms of pharmacological rescue of trafficking-defective hERG mutant channels in human long QT syndrome.
|
16361248 |
2006 |
Long Qt Syndrome 2
|
|
0.820 |
GeneticVariation
|
UNIPROT |
A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome.
|
7889573 |
1995 |
Long Qt Syndrome 2
|
|
0.820 |
GeneticVariation
|
UNIPROT |
Spectrum of pathogenic mutations and associated polymorphisms in a cohort of 44 unrelated patients with long QT syndrome.
|
16922724 |
2006 |
Long Qt Syndrome 2
|
|
0.820 |
GeneticVariation
|
UNIPROT |
Long QT syndrome-associated mutations in the Per-Arnt-Sim (PAS) domain of HERG potassium channels accelerate channel deactivation.
|
10187793 |
1999 |
Long Qt Syndrome 2
|
|
0.820 |
GeneticVariation
|
UNIPROT |
Novel missense mutation (G601S) of HERG in a Japanese long QT syndrome family.
|
9452080 |
1998 |
Long Qt Syndrome 2
|
|
0.820 |
GeneticVariation
|
UNIPROT |
Novel KCNQ1 and HERG missense mutations in Dutch long-QT families.
|
10220144 |
1999 |
Long Qt Syndrome 2
|
|
0.820 |
GeneticVariation
|
BEFREE |
In the present study, we investigated the functional consequences of the LQT2 mutation G628S in the hERG1b and hERG1a(USO) isoforms.
|
22876326 |
2012 |
Long Qt Syndrome 2
|
|
0.820 |
GeneticVariation
|
UNIPROT |
Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2.
|
10973849 |
2000 |
Long Qt Syndrome 2
|
|
0.820 |
GeneticVariation
|
UNIPROT |
Characterization of a novel missense mutation in the pore of HERG in a patient with long QT syndrome.
|
10517660 |
1999 |
Long Qt Syndrome 2
|
|
0.820 |
GeneticVariation
|
UNIPROT |
Novel missense mutation in the cyclic nucleotide-binding domain of HERG causes long QT syndrome.
|
8914737 |
1996 |
Long Qt Syndrome 2
|
|
0.820 |
GeneticVariation
|
UNIPROT |
Clinical, genetic, and biophysical characterization of a homozygous HERG mutation causing severe neonatal long QT syndrome.
|
12621127 |
2003 |