| Disease | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
CLAPO Syndrome
|
0.800 | CausalMutation | CLINVAR | ||||||||
Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal Nevi
|
0.700 | CausalMutation | CLINVAR | ||||||||
ovarian neoplasm
|
0.700 | CausalMutation | CLINVAR | ||||||||
Colorectal Neoplasms
|
0.700 | CausalMutation | CLINVAR | The PIK3CA gene is mutated with high frequency in human breast cancers. | 15254419 | 2004 | |||||
Colorectal Neoplasms
|
0.700 | CausalMutation | CLINVAR | High frequency of mutations of the PIK3CA gene in human cancers. | 15016963 | 2004 | |||||
Mammary Neoplasms
|
0.700 | CausalMutation | CLINVAR | The PIK3CA gene is mutated with high frequency in human breast cancers. | 15254419 | 2004 | |||||
Non-Small Cell Lung Carcinoma
|
0.700 | CausalMutation | CLINVAR | The PIK3CA gene is mutated with high frequency in human breast cancers. | 15254419 | 2004 | |||||
Non-Small Cell Lung Carcinoma
|
0.700 | CausalMutation | CLINVAR | High frequency of mutations of the PIK3CA gene in human cancers. | 15016963 | 2004 | |||||
Colorectal Neoplasms
|
0.700 | CausalMutation | CLINVAR | Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. | 15647370 | 2005 | |||||
Mammary Neoplasms
|
0.700 | CausalMutation | CLINVAR | Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. | 15647370 | 2005 | |||||
ovarian neoplasm
|
0.700 | CausalMutation | CLINVAR | Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. | 15647370 | 2005 | |||||
Non-Small Cell Lung Carcinoma
|
0.700 | CausalMutation | CLINVAR | Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. | 15647370 | 2005 | |||||
Mammary Neoplasms
|
0.700 | CausalMutation | CLINVAR | PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma. | 15805248 | 2005 | |||||
Non-Small Cell Lung Carcinoma
|
0.700 | CausalMutation | CLINVAR | Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer. | 16906227 | 2006 | |||||
Non-Small Cell Lung Carcinoma
|
0.700 | CausalMutation | CLINVAR | PIK3CA mutation status in Japanese lung cancer patients. | 16930767 | 2006 | |||||
Colorectal Neoplasms
|
0.700 | CausalMutation | CLINVAR | Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling. | 18725974 | 2008 | |||||
Non-Small Cell Lung Carcinoma
|
0.700 | CausalMutation | CLINVAR | Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling. | 18725974 | 2008 | |||||
Mammary Neoplasms
|
0.700 | CausalMutation | CLINVAR | An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer. | 18676830 | 2008 | |||||
Non-Small Cell Lung Carcinoma
|
0.700 | CausalMutation | CLINVAR | Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. | 19029981 | 2008 | |||||
Mammary Neoplasms
|
0.700 | CausalMutation | CLINVAR | Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling. | 18725974 | 2008 | |||||
Colorectal Neoplasms
|
0.700 | CausalMutation | CLINVAR | PIK3CA mutations are not a major determinant of resistance to the epidermal growth factor receptor inhibitor cetuximab in metastatic colorectal cancer. | 19366826 | 2009 | |||||
Colorectal Neoplasms
|
0.700 | CausalMutation | CLINVAR | PIK3CA mutations predict local recurrences in rectal cancer patients. | 19903786 | 2009 | |||||
Colorectal Neoplasms
|
0.700 | CausalMutation | CLINVAR | PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies. | 19223544 | 2009 | |||||
Non-Small Cell Lung Carcinoma
|
0.700 | CausalMutation | CLINVAR | A novel dual PI3Kalpha/mTOR inhibitor PI-103 with high antitumor activity in non-small cell lung cancer cells. | 19513541 | 2009 | |||||
Colorectal Neoplasms
|
0.700 | CausalMutation | CLINVAR | Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical models. | 20453058 | 2010 |