rs121913377, BRAF

N. diseases: 480
Disease: keratoacanthoma ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
keratoacanthoma
CUI: C0022572
Disease: keratoacanthoma
0.020 GeneticVariation BEFREE In clinical trials trametinib, a MEK inhibitor (MEKi) increases BRAFi therapy efficacy in BRAF(V600E) melanomas and reduces BRAFi-induced KA and cuSCC frequency. 24345644 2014
keratoacanthoma
CUI: C0022572
Disease: keratoacanthoma
0.020 GeneticVariation BEFREE RAF inhibitors are effective against melanomas with BRAF V600E mutations but may induce keratoacanthomas (KAs) and cutaneous squamous cell carcinomas (cSCCs). 22067401 2012