rs121913459, ABL1

N. diseases: 25
Disease: Leukemia, Myeloid, Chronic-Phase ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Leukemia, Myeloid, Chronic-Phase
CUI: C0023474
Disease: Leukemia, Myeloid, Chronic-Phase
0.030 GeneticVariation BEFREE These results confirm early assumptions concerning the poor prognosis of chronic phase chronic myelogenous leukemia patients with the T315I mutation who are not eligible for allogeneic transplantation, and demonstrate the need for more therapeutic options. 23716543 2013
Leukemia, Myeloid, Chronic-Phase
CUI: C0023474
Disease: Leukemia, Myeloid, Chronic-Phase
0.030 GeneticVariation BEFREE Phase 2 study of subcutaneous omacetaxine mepesuccinate after TKI failure in patients with chronic-phase CML with T315I mutation. 22896000 2012
Leukemia, Myeloid, Chronic-Phase
CUI: C0023474
Disease: Leukemia, Myeloid, Chronic-Phase
0.030 GeneticVariation BEFREE The durable clearance of the T315I BCR-ABL mutated clone in chronic phase chronic myelogenous leukemia patients on omacetaxine allows tyrosine kinase inhibitor rechallenge. 21030353 2010