|
Prostate carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study demonstrates that IDH1 R132H mutation with increased oncometabolite R-2HG in PCa cells may play important roles to increase PCa cell invasion.
|
31846689 |
2020 |
|
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Preclinical studies with an in vivo xenograft mouse model also revealed that PCa cells with the IDH1 R132H mutation have more invasive metastasis.
|
31846689 |
2020 |
|
Malignant neoplasm of prostate
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study demonstrates that IDH1 R132H mutation with increased oncometabolite R-2HG in PCa cells may play important roles to increase PCa cell invasion.
|
31846689 |
2020 |
|
Glioblastoma, IDH-Wildtype
|
|
0.010 |
GeneticVariation
|
BEFREE |
IDH1 (R132H) mutation was observed in 5/75 primary GBs.
|
31479414 |
2020 |
|
Neoplasm, Residual
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition to WT1 overexpression, other MRD positive markers were: NPM1 (Type A, B, K), DNMT3A (R882H), MLL-PTD, IDH1 (R132H) and KRAS (G12S).
|
30457973 |
2019 |
|
Malignant neoplasm of brain
|
|
0.010 |
GeneticVariation
|
BEFREE |
The R132H mutation in isocitrate dehydrogenase 1 (IDH1<sup>R132H</sup>) is commonly observed and associated with better survival in glioblastoma multiforme (GBM), a malignant brain tumor.
|
31151327 |
2019 |
|
Li-Fraumeni Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
One patient was diagnosed with multicentric isocitrate dehydrogenase 1 (IDH1) mutated diffuse astrocytomas harboring distinct IDH1 mutations, R132H and R132C; the latter mutation has been associated with Li-Fraumeni syndrome, which was subsequently confirmed in the patient's germline DNA and shown in additional cases with The Cancer Genome Atlas data.
|
29077933 |
2018 |
|
Atypical Lipoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Because many ALT tumors express the mutant isocitrate dehydrogenase IDH1 R132H, including all lower grade astrocytomas and secondary glioblastoma, we examined a hypothesized role for IDH1 R132H in driving the ALT phenotype during gliomagenesis.
|
29545335 |
2018 |
|
Non-Small Cell Lung Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study, we suggest an innovative model for IDH1 R132H/Fibulin-5 pathway, which could throw light upon the activity of IDH1 R132H in NSCLC.
|
30305430 |
2018 |
|
Epileptic Seizures
|
|
0.010 |
GeneticVariation
|
BEFREE |
In a multivariate analysis, high xCT expression and WHO tumor grade but not IDH1 R132H mutation, were significantly associated with epileptic seizures at diagnosis (odds ratio 2.2, p = 0.02).
|
29404978 |
2018 |
|
Leukemia secondary
|
|
0.010 |
GeneticVariation
|
BEFREE |
We studied the development of somatic mutations in t-MN, using a collection of follow-up samples from 14 patients with a primary hematologic malignancy, who developed a secondary leukemia (13 t-MN and 1 t-acute lymphoblastic leukemia), at a median latency of 73 months (range 18-108) from primary cancer diagnosis.Using Sanger and next generation sequencing (NGS) approaches we identified 8 mutations (IDH1 R132H, ASXL1 Y591*, ASXL1 S689*, ASXL1 R693*, SRSF2 P95H, SF3B1 K700E, SETBP1 G870R and TP53 Y220C) in seven of thirteen t-MN patients (54%), whereas the t-ALL patient had a t(4,11) translocation, resulting in the KMT2A/AFF1 fusion gene.
|
28076841 |
2017 |
|
Spinal Cord Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genetic analysis of both the supratentorial and spinal tumours revealed R132H IDH1 mutations, providing evidence that the spinal cord lesion had spread from the supratentorial tumour.
|
28089418 |
2017 |
|
High grade glioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
En bloc resection revealed a high-grade glioma with sarcomatous components that was immunoreactive for the R132H variant of IDH1 by antibody.
|
27153165 |
2017 |
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In both gastric and colorectal cancer, expression of IDH1-R132H was associated with tumor stage.
|
27655638 |
2016 |
|
Malignant neoplasm of gastrointestinal tract
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our data indicate that IDH1-R132H expression could be used as a predictive marker of prognosis for patients with gastrointestinal cancer.
|
27655638 |
2016 |
|
Uveal melanoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
All 50 of the uveal melanoma cases demonstrated negativity for IDH1-R132H by immunohistochemistry.
|
27155448 |
2016 |
|
Intrahepatic Cholangiocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Immunohistochemistry using monoclonal antibody MsMab-2 is useful to detect IDH1 R132L in intrahepatic cholangiocarcinoma.
|
27595804 |
2016 |
|
Primary cholangiocarcinoma of intrahepatic biliary tract
|
|
0.010 |
GeneticVariation
|
BEFREE |
Immunohistochemistry using monoclonal antibody MsMab-2 is useful to detect IDH1 R132L in intrahepatic cholangiocarcinoma.
|
27595804 |
2016 |
|
Adult Anaplastic Oligodendroglioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The R132H IDH1 mutation was identified in 43/117 tumor samples and R172K IDH2 mutation was detected in only one anaplastic oligodendroglioma.
|
27268645 |
2016 |
|
Childhood Anaplastic Oligodendroglioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The R132H IDH1 mutation was identified in 43/117 tumor samples and R172K IDH2 mutation was detected in only one anaplastic oligodendroglioma.
|
27268645 |
2016 |
|
Malignant neoplasm of colon and/or rectum
|
|
0.010 |
GeneticVariation
|
BEFREE |
In both gastric and colorectal cancer, expression of IDH1-R132H was associated with tumor stage.
|
27655638 |
2016 |
|
Pilocytic astrocytoma of cerebellum
|
|
0.010 |
GeneticVariation
|
BEFREE |
We present the case of a 72-year old female with a right cerebellar pilocytic astrocytoma WHO grade I with an Isocitrate dehydrogenase 1 (IDH1) R132H mutation.
|
26617931 |
2015 |
|
Adult Pilocytic Astrocytoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
IDH1 R132H mutation in a pilocytic astrocytoma: a case report.
|
26617931 |
2015 |
|
Recurrent Childhood Glioblastoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to explore the difference in high mobility group A1 (HMGA1) expression and isocitrate dehydrogenase (IDH) 1 R132H point mutation in initial and recurrent glioblastoma multiforme (GBM), and to further identify whether the expression of HMGA1 has a role in the malignant progression of GBM.
|
26092597 |
2015 |
|
Childhood Pilocytic Astrocytoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
IDH1 R132H mutation in a pilocytic astrocytoma: a case report.
|
26617931 |
2015 |