|
GLIOMA SUSCEPTIBILITY 1
|
|
0.700 |
GeneticVariation
|
UNIPROT |
IDH1 and IDH2 mutations in gliomas.
|
19228619 |
2009 |
|
Leukemia, Myelocytic, Acute
|
|
0.720 |
CausalMutation
|
CLINVAR |
We found three missense (p.R132C, p.R132G, and p.I99M; occurred in five patients) and one silent mutation (c.315C>T; occurred in two patients) in the IDH1 gene and two missense mutations (p.R140Q and p.R172K; occurred in four AML patients) and one silent mutation (c.435G>A) in the IDH2 gene.
|
20946881 |
2010 |
|
Leukemia, Myelocytic, Acute
|
|
0.720 |
GeneticVariation
|
BEFREE |
We found three missense (p.R132C, p.R132G, and p.I99M; occurred in five patients) and one silent mutation (c.315C>T; occurred in two patients) in the IDH1 gene and two missense mutations (p.R140Q and p.R172K; occurred in four AML patients) and one silent mutation (c.435G>A) in the IDH2 gene.
|
20946881 |
2010 |
|
Leukemia, Myelocytic, Acute
|
|
0.720 |
CausalMutation
|
CLINVAR |
Evaluation of mutations in the isocitrate dehydrogenase genes in therapy-related and secondary acute myeloid leukaemia identifies a patient with clonal evolution to IDH2 R172K homozygosity due to uniparental disomy.
|
21250968 |
2011 |
|
Leukemia, Myelocytic, Acute
|
|
0.720 |
CausalMutation
|
CLINVAR |
Impact of genetic features on treatment decisions in AML.
|
22160010 |
2011 |
|
Leukemia, Myelocytic, Acute
|
|
0.720 |
CausalMutation
|
CLINVAR |
Impact of genetic features on treatment decisions in AML.
|
22160010 |
2011 |
|
Leukemia, Myelocytic, Acute
|
|
0.720 |
CausalMutation
|
CLINVAR |
The prognostic significance of IDH2 mutations in AML depends on the location of the mutation.
|
21596855 |
2011 |
|
oligodendroglioma
|
|
0.020 |
GeneticVariation
|
BEFREE |
A c.515G>T (p.R172M) mutation of the IDH2 gene was only identified in a grade II oligodendroglioma patient which was wild-type for IDH1.
|
21643842 |
2011 |
|
Well Differentiated Oligodendroglioma
|
|
0.020 |
GeneticVariation
|
BEFREE |
A c.515G>T (p.R172M) mutation of the IDH2 gene was only identified in a grade II oligodendroglioma patient which was wild-type for IDH1.
|
21643842 |
2011 |
|
Childhood Oligodendroglioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
A c.515G>T (p.R172M) mutation of the IDH2 gene was only identified in a grade II oligodendroglioma patient which was wild-type for IDH1.
|
21643842 |
2011 |
|
Adult Oligodendroglioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
A c.515G>T (p.R172M) mutation of the IDH2 gene was only identified in a grade II oligodendroglioma patient which was wild-type for IDH1.
|
21643842 |
2011 |
|
Leukemia, Myelocytic, Acute
|
|
0.720 |
CausalMutation
|
CLINVAR |
Potential application of IDH1 and IDH2 mutations as prognostic indicators in non-promyelocytic acute myeloid leukemia: a meta-analysis.
|
22616558 |
2012 |
|
Leukemia, Myelocytic, Acute
|
|
0.720 |
CausalMutation
|
CLINVAR |
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia.
|
22417203 |
2012 |
|
Leukemia, Myelocytic, Acute
|
|
0.720 |
CausalMutation
|
CLINVAR |
Molecular alterations of isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) metabolic genes and additional genetic mutations in newly diagnosed acute myeloid leukemia patients.
|
22397365 |
2012 |
|
Leukemia, Myelocytic, Acute
|
|
0.720 |
CausalMutation
|
CLINVAR |
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia.
|
22417203 |
2012 |
|
Leukemia, Myelocytic, Acute
|
|
0.720 |
CausalMutation
|
CLINVAR |
The role of mutations in epigenetic regulators in myeloid malignancies.
|
22898539 |
2012 |
|
Leukemia, Myelocytic, Acute
|
|
0.720 |
GeneticVariation
|
BEFREE |
Rapid detection of IDH2 (R140Q and R172K) mutations in acute myeloid leukemia.
|
23949315 |
2013 |
|
Leukemia, Myelocytic, Acute
|
|
0.720 |
CausalMutation
|
CLINVAR |
Rapid detection of IDH2 (R140Q and R172K) mutations in acute myeloid leukemia.
|
23949315 |
2013 |
|
Childhood Glioblastoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Overexpression of IDH1(R132H) and IDH2(R172K) mutant protein in glioblastoma cells resulted in increased radiation sensitivity and altered ROS metabolism and suppression of growth and migration in vitro.
|
23115158 |
2013 |
|
Spindle cell hemangioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The R132C IDH1 mutation was identified by hydrolysis probes assay and confirmed by Sanger sequencing in 18 of 28 (64%) SCHs; of the 10 negative cases, 2 harbored a mutation in IDH2 (R172T and R172M) by Sanger sequencing.
|
23485734 |
2013 |
|
Adult Glioblastoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Overexpression of IDH1(R132H) and IDH2(R172K) mutant protein in glioblastoma cells resulted in increased radiation sensitivity and altered ROS metabolism and suppression of growth and migration in vitro.
|
23115158 |
2013 |
|
Glioblastoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Overexpression of IDH1(R132H) and IDH2(R172K) mutant protein in glioblastoma cells resulted in increased radiation sensitivity and altered ROS metabolism and suppression of growth and migration in vitro.
|
23115158 |
2013 |
|
Glioblastoma Multiforme
|
|
0.010 |
GeneticVariation
|
BEFREE |
Overexpression of IDH1(R132H) and IDH2(R172K) mutant protein in glioblastoma cells resulted in increased radiation sensitivity and altered ROS metabolism and suppression of growth and migration in vitro.
|
23115158 |
2013 |
|
Leukemia, Myelocytic, Acute
|
|
0.720 |
CausalMutation
|
CLINVAR |
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
|
25157968 |
2014 |
|
Leukemia, Myelocytic, Acute
|
|
0.720 |
CausalMutation
|
CLINVAR |
Molecular evaluation of DNMT3A and IDH1/2 gene mutation: frequency, distribution pattern and associations with additional molecular markers in normal karyotype Indian acute myeloid leukemia patients.
|
24606448 |
2014 |