rs121913529, KRAS

N. diseases: 144
Disease: ADENOMAS AND ADENOCARCINOMAS ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
ADENOMAS AND ADENOCARCINOMAS
CUI: C1535510
Disease: ADENOMAS AND ADENOCARCINOMAS
0.010 GeneticVariation BEFREE Using genetically engineered mouse models (GEMMs) for human non-small-cell lung cancer (NSCLC), we found that deletion of the essential autophagy gene, Atg7, in KRAS(G12D)-driven NSCLC inhibits tumor growth and converts adenomas and adenocarcinomas to benign oncocytomas characterized by the accumulation of respiration-defective mitochondria. 23959381 2013