|
Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our meta-analysis showed that AMPK pathway had significant associations with progression-free survival (PFS; p < 0.001) and overall survival (OS; p < 0.001), but not with tumor response (TR; p = 0.220): PRKAA1 rs13361707 was significantly associated with favorable PFS (log HR = -0.219, SE = 0.073, p = 0.003), as well as PRKAA1 rs10074991 (log HR = -0.215, SE = 0.073, p = 0.003), and there were suggestive associations of PRKAG1 rs1138908 with unfavorable OS (log HR = 0.170, SE = 0.083, p = 0.041), and of UBE2O rs3803739 with unfavorable PFS (log HR = 0.137, SE = 0.068, p = 0.042) and OS (log HR = 0.210, SE = 0.077, p = 0.006), although these results were not significant after false discovery rate adjustment.
|
30856283 |
2019 |
|
Intestinal metaplasia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Moreover, three SNPs, MUC1 rs4072037, ZBTB20 rs9841504 and PRKAA1 rs13361707, were associated with precancerous gastric lesions (severe IM/dysplasia).
|
28220687 |
2017 |
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
To sum up, PRKAA1 rs13361707 polymorphism is not participant with the increased risk of cancer, while the A allele of PRKAA1 rs10074991 revealed a significant decrease risk.
|
30340465 |
2018 |
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
To sum up, PRKAA1 rs13361707 polymorphism is not participant with the increased risk of cancer, while the A allele of PRKAA1 rs10074991 revealed a significant decrease risk.
|
30340465 |
2018 |
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
Also those with a hereditary background including the risk alleles PLCE1 rs2274223 and PTGER4/PRKAA1 rs13361707 were 3 times more susceptible to cardia cancer than those without.
|
27127881 |
2016 |
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
Also those with a hereditary background including the risk alleles PLCE1 rs2274223 and PTGER4/PRKAA1 rs13361707 were 3 times more susceptible to cardia cancer than those without.
|
27127881 |
2016 |
|
Schizophrenia
|
|
0.700 |
GeneticVariation
|
GWASDB |
Common variants on 8p12 and 1q24.2 confer risk of schizophrenia.
|
22037555 |
2011 |
|
Stomach Carcinoma
|
|
0.780 |
GeneticVariation
|
BEFREE |
TLR1 rs4833095 SNP was associated with an increased risk of GC in a European population, while PRKAA1 rs13361707 genetic variant was not linked with GC.
|
30574617 |
2018 |
|
Malignant neoplasm of stomach
|
|
0.780 |
GeneticVariation
|
BEFREE |
In similar, an increased risk of gastric cancer was also observed for rs13361707</span> TC genotype (adjusted OR = 1.47, 95%CI: 1.01-2.14, p = 0.043; additive model: adjusted OR = 1.22, 95%CI: 1.02-1.47, p = 0.033).
|
30253744 |
2018 |
|
Stomach Carcinoma
|
|
0.780 |
GeneticVariation
|
BEFREE |
The meta-analysis reveals that the PRKAA1 rs13361707 T>C polymorphism has a significant relationship with increased GC risk.
|
29620653 |
2018 |
|
Stomach Carcinoma
|
|
0.780 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies gastric cancer susceptibility loci at 12q24.11-12 and 20q11.21.
|
30281874 |
2018 |
|
Malignant neoplasm of stomach
|
|
0.780 |
GeneticVariation
|
BEFREE |
TLR1 rs4833095 SNP was associated with an increased risk of GC in a European population, while PRKAA1 rs13361707 genetic variant was not linked with GC.
|
30574617 |
2018 |
|
Stomach Carcinoma
|
|
0.780 |
GeneticVariation
|
BEFREE |
In similar, an increased risk of gastric cancer was also observed for rs13361707</span> TC genotype (adjusted OR = 1.47, 95%CI: 1.01-2.14, p = 0.043; additive model: adjusted OR = 1.22, 95%CI: 1.02-1.47, p = 0.033).
|
30253744 |
2018 |
|
Malignant neoplasm of stomach
|
|
0.780 |
GeneticVariation
|
BEFREE |
The meta-analysis reveals that the PRKAA1 rs13361707 T>C polymorphism has a significant relationship with increased GC risk.
|
29620653 |
2018 |
|
Stomach Carcinoma
|
|
0.780 |
GeneticVariation
|
BEFREE |
Correlation between protein kinase catalytic subunit alpha-1 gene rs13361707 polymorphism and gastric cancer susceptibility in asian populations.
|
28978122 |
2017 |
|
Malignant neoplasm of stomach
|
|
0.780 |
GeneticVariation
|
BEFREE |
Correlation between protein kinase catalytic subunit alpha-1 gene rs13361707 polymorphism and gastric cancer susceptibility in asian populations.
|
28978122 |
2017 |
|
Stomach Carcinoma
|
|
0.780 |
GeneticVariation
|
GWASCAT |
Identification of new susceptibility loci for gastric non-cardia adenocarcinoma: pooled results from two Chinese genome-wide association studies.
|
26701879 |
2017 |
|
Stomach Carcinoma
|
|
0.780 |
GeneticVariation
|
BEFREE |
In summary, these results indicated that the C allele of PRKAA1 rs13361707 was a low-penetrate risk factor for GCa.
|
26485766 |
2015 |
|
Malignant neoplasm of stomach
|
|
0.780 |
GeneticVariation
|
BEFREE |
In summary, these results indicated that the C allele of PRKAA1 rs13361707 was a low-penetrate risk factor for GCa.
|
26485766 |
2015 |
|
Malignant neoplasm of stomach
|
|
0.780 |
GeneticVariation
|
BEFREE |
In the dominant model, SNPs rs13361707 [odds ratio (OR) = 1.51, 95%CI: 1.07-2.11)], rs154268 (OR = 1.65, 95%CI: 1.22-2.22), rs6882903 (OR = 1.48, 95%CI: 1.09-2.00), and rs10074991 (OR = 1.53, 95%CI: 1.09-2.16) were significantly associated with an increased risk of gastric cancer.
|
25024613 |
2014 |
|
Stomach Carcinoma
|
|
0.780 |
GeneticVariation
|
BEFREE |
In the dominant model, SNPs rs13361707 [odds ratio (OR) = 1.51, 95%CI: 1.07-2.11)], rs154268 (OR = 1.65, 95%CI: 1.22-2.22), rs6882903 (OR = 1.48, 95%CI: 1.09-2.00), and rs10074991 (OR = 1.53, 95%CI: 1.09-2.16) were significantly associated with an increased risk of gastric cancer.
|
25024613 |
2014 |
|
Stomach Carcinoma
|
|
0.780 |
GeneticVariation
|
BEFREE |
Our study showed that the rs13361707 polymorphism was associated with increased risk of gastric cancer in a Korean population.
|
23861218 |
2013 |
|
Stomach Carcinoma
|
|
0.780 |
GeneticVariation
|
BEFREE |
These findings indicate that the three SNPs (rs4072037, rs13361707 and rs2274223) identified in the GWASs may interact with H. pylori infection to increase the risk of GC.
|
24069371 |
2013 |
|
Malignant neoplasm of stomach
|
|
0.780 |
GeneticVariation
|
BEFREE |
These findings indicate that the three SNPs (rs4072037, rs13361707 and rs2274223) identified in the GWASs may interact with H. pylori infection to increase the risk of GC.
|
24069371 |
2013 |
|
Malignant neoplasm of stomach
|
|
0.780 |
GeneticVariation
|
BEFREE |
Our study showed that the rs13361707 polymorphism was associated with increased risk of gastric cancer in a Korean population.
|
23861218 |
2013 |