|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
UNIPROT |
|
|
|
|
Malignant neoplasm of breast
|
|
0.720 |
CausalMutation
|
CLINVAR |
|
|
|
|
Prostate Cancer, Hereditary, 9
|
|
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
Malignant neoplasm of ovary
|
|
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
PROSTATE CANCER, SUSCEPTIBILITY TO
|
|
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
Malignant tumor of colon
|
|
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
Neoplastic Syndromes, Hereditary
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity.
|
8756292 |
1996 |
|
Neoplastic Syndromes, Hereditary
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Hoxb13 up-regulates transglutaminase activity and drives terminal differentiation in an epidermal organotypic model.
|
15964834 |
2005 |
|
Neoplastic Syndromes, Hereditary
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Posterior Hox gene expression and differential androgen regulation in the developing and adult rat prostate lobes.
|
17138648 |
2007 |
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
The G84E mutation was more frequent among white case subjects than among white control subjects (10 of 1525 [0.7%] vs 2 of 1757 [0.1%], P = .01) and was associated with an increased risk of prostate cancer (unadjusted odds ratio = 5.8, 95% confidence interval = 1.3 to 26.5, P = .01).
|
22781434 |
2012 |
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The germline mutation G84E of HOXB13 is a rare but recurrent mutation associated with elevated risk of prostate cancer in men of European descent, with an effect size that is greater than observed for previously validated risk variants of genome wide association studies.
|
22714738 |
2012 |
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The G84E mutation was more frequent among white case subjects than among white control subjects (10 of 1525 [0.7%] vs 2 of 1757 [0.1%], P = .01) and was associated with an increased risk of prostate cancer (unadjusted odds ratio = 5.8, 95% confidence interval = 1.3 to 26.5, P = .01).
|
22781434 |
2012 |
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
The germline mutation G84E of HOXB13 is a rare but recurrent mutation associated with elevated risk of prostate cancer in men of European descent, with an effect size that is greater than observed for previously validated risk variants of genome wide association studies.
|
22714738 |
2012 |
|
Malignant neoplasm of breast
|
|
0.720 |
GeneticVariation
|
BEFREE |
This study does not support the hypothesis that women who carry the HOXB13 Gly84Glu mutation are at increased risk of breast cancer.
|
23099437 |
2012 |
|
Neoplastic Syndromes, Hereditary
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Association of a HOXB13 variant with breast cancer.
|
22853031 |
2012 |
|
Neoplastic Syndromes, Hereditary
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Confirmation of the HOXB13 G84E germline mutation in familial prostate cancer.
|
22714738 |
2012 |
|
Neoplastic Syndromes, Hereditary
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Germline mutations in HOXB13 and prostate-cancer risk.
|
22236224 |
2012 |
|
Neoplastic Syndromes, Hereditary
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Association between germline HOXB13 G84E mutation and risk of prostate cancer.
|
22781434 |
2012 |
|
Prostate cancer, familial
|
|
0.060 |
GeneticVariation
|
BEFREE |
The novel HOXB13 G84E variant is associated with a significantly increased risk of hereditary prostate cancer.
|
22236224 |
2012 |
|
Prostate cancer, familial
|
|
0.060 |
GeneticVariation
|
BEFREE |
We evaluated the G84E germline mutation (rs138213197) of HOXB13 in a case-control study of familial prostate cancer at Vanderbilt University (Nashville, TN) to independently evaluate the association of the mutation with familial prostate cancer.
|
22714738 |
2012 |
|
Hereditary Prostate Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
The novel HOXB13 G84E variant is associated with a significantly increased risk of hereditary prostate cancer.
|
22236224 |
2012 |
|
Breast Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
This study does not support the hypothesis that women who carry the HOXB13 Gly84Glu mutation are at increased risk of breast cancer.
|
23099437 |
2012 |
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
We performed a retrospective analysis of germline DNA samples from Ashkenazi Jewish men and a comparison group of non-Ashkenazi men treated for prostate cancer at our institution to determine the prevalence of HOXB13 G84E mutation in prostate cancer patients of Ashkenazi Jewish heritage, an ethnic group common to the New York City area.
|
23475555 |
2013 |
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
These findings demonstrate that the HOXB13 G84E mutation is present in ~5 % of prostate cancer families, predominantly of European descent, and confirm its association with prostate cancer risk.
|
23064873 |
2013 |
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our study has provided a population-based estimate of the average risk of prostate cancer for HOXB13 missense mutation G84E carriers that can be used to guide clinical practice and research.
|
23457453 |
2013 |