|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
Then, 25 studies including 51,390 cases and 93,867 controls were included, and there was significant association between HOXB13 p.Gly84Glu mutation and overall cancer risk (OR = 2.872, 95% CI = 2.121-3.888, P < 0.001), particularly in prostate cancer (OR = 3.248, 95% CI = 2.313-4.560, P < 0.001), while no association was found in breast (OR = 1.424, 95% CI = 0.776-2.613, P = 0.253) and colorectal cancers (OR = 2.070, 95% CI = 0.485-8.841, P = 0.326).
|
26517352 |
2015 |
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our study confirms the association between the HOXB13 G84E variant and prostate cancer and suggests a novel association between G84E and leukemia and a suggestive association with bladder cancer.
|
26108461 |
2015 |
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
While the HOXB13 G84E mutation may be rare, there may be a future role in genetic testing for this mutation after further studies of clinical utility in assessing prostate cancer risk.
|
24310616 |
2014 |
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
HOXB13 G84E is prevalent in >1% of the Swedish population and is associated with a 3.5-fold increased risk of prostate cancer.
|
22841674 |
2014 |
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
Additional genotyping, conditional regression and haplotype analyses indicated that the newly identified common variants tag a rare, partially correlated coding variant in the HOXB13 gene (G84E, rs138213197), which has been identified recently as a moderate penetrance PrCa susceptibility allele.
|
24550738 |
2014 |
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
HOXB13 G84E is prevalent in >1% of the Swedish population and is associated with a 3.5-fold increased risk of prostate cancer.
|
22841674 |
2014 |
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
In the present study, carriers of the rare G84E variant in HOXB13 were both younger at the time of diagnosis and more likely to have a family history of prostate cancer compared with homozygotes for the wild-type allele.
|
24148311 |
2014 |
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
While the HOXB13 G84E mutation may be rare, there may be a future role in genetic testing for this mutation after further studies of clinical utility in assessing prostate cancer risk.
|
24310616 |
2014 |
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
In summary, HOXB13 G84E variant-related prostate cancers show frequent pseudohyperplastic-type features and markedly low prevalence of ERG cancers relative to unselected cases and, especially, to early-onset cohorts.
|
24722062 |
2014 |
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Recent genetic epidemiologic studies identified a germline mutation in the homeobox transcription factor, HOXB13 G84E, which is associated with markedly increased risk for prostate cancer, particularly early-onset hereditary prostate cancer.
|
24722062 |
2014 |
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
In the present study, carriers of the rare G84E variant in HOXB13 were both younger at the time of diagnosis and more likely to have a family history of prostate cancer compared with homozygotes for the wild-type allele.
|
24148311 |
2014 |
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
G84E mutation in HOXB13 is firmly associated with prostate cancer risk: a meta-analysis.
|
24026887 |
2014 |
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Additional genotyping, conditional regression and haplotype analyses indicated that the newly identified common variants tag a rare, partially correlated coding variant in the HOXB13 gene (G84E, rs138213197), which has been identified recently as a moderate penetrance PrCa susceptibility allele.
|
24550738 |
2014 |
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
G84E mutation in HOXB13 is firmly associated with prostate cancer risk: a meta-analysis.
|
24026887 |
2014 |
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
We performed a retrospective analysis of germline DNA samples from Ashkenazi Jewish men and a comparison group of non-Ashkenazi men treated for prostate cancer at our institution to determine the prevalence of HOXB13 G84E mutation in prostate cancer patients of Ashkenazi Jewish heritage, an ethnic group common to the New York City area.
|
23475555 |
2013 |
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
These findings demonstrate that the HOXB13 G84E mutation is present in ~5 % of prostate cancer families, predominantly of European descent, and confirm its association with prostate cancer risk.
|
23064873 |
2013 |
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our study has provided a population-based estimate of the average risk of prostate cancer for HOXB13 missense mutation G84E carriers that can be used to guide clinical practice and research.
|
23457453 |
2013 |
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
There was a stronger association between the G84E variant and PC among men with no first-degree relative with PC (OR, 4.04; 95% CI, 1.12-14.51) compared to men with a family history of PC (OR, 1.49; 95% CI, 0.30-7.50; P = 0.36 for interaction).
|
23129385 |
2013 |
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
The G84E mutation predisposes to prostate cancer in Poland, but accounts for only a small proportion of cases.
|
23334858 |
2013 |
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
In conclusion, the G84E mutation of HOXB13, a relatively recent mutation that likely occurred in Northern Europe, significantly increases risk for PCa.
|
23393222 |
2013 |
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Testing for the G84E mutation in men with a positive family history may help distinguish those who merit more regular screening for prostate cancer.
|
23396964 |
2013 |
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
A rare mutation G84E in HOXB13 was recently identified to be associated with prostate cancer (PCa) in Caucasians.
|
22718278 |
2013 |
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
We performed a retrospective analysis of germline DNA samples from Ashkenazi Jewish men and a comparison group of non-Ashkenazi men treated for prostate cancer at our institution to determine the prevalence of HOXB13 G84E mutation in prostate cancer patients of Ashkenazi Jewish heritage, an ethnic group common to the New York City area.
|
23475555 |
2013 |
|
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
This study confirms the overall importance of the HOXB13 G84E mutation in prostate cancer susceptibility.
|
23292082 |
2013 |
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
In conclusion, the G84E mutation of HOXB13, a relatively recent mutation that likely occurred in Northern Europe, significantly increases risk for PCa.
|
23393222 |
2013 |