Immune thrombocytopenic purpura
|
|
0.020 |
GeneticVariation
|
BEFREE |
Interleukin-27 rs153109 polymorphism and the risk for immune thrombocytopenia.
|
23937109 |
2013 |
Autoimmune thrombocytopenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Interleukin-27 rs153109 polymorphism and the risk for immune thrombocytopenia.
|
23937109 |
2013 |
Thrombocytopenia due to platelet alloimmunization
|
|
0.010 |
GeneticVariation
|
BEFREE |
Interleukin-27 rs153109 polymorphism and the risk for immune thrombocytopenia.
|
23937109 |
2013 |
Allergic rhinitis (disorder)
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study indicates that IL-27p28 polymorphisms rs153109 and rs17855750 are likely involved in AR susceptibility, making them potentially useful genetic biomarkers for AR susceptibility in the Chinese Han population.
|
25075448 |
2014 |
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of the present study was to investigate the association between a potentially functional polymorphism (rs153109, -964A>G) at the promoter of IL-27 and the risk of breast cancer in a Chinese population.
|
25146683 |
2014 |
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of the present study was to investigate the association between a potentially functional polymorphism (rs153109, -964A>G) at the promoter of IL-27 and the risk of breast cancer in a Chinese population.
|
25146683 |
2014 |
Hepatitis C
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our work provides preliminary information for a standardized method potentially useful for genotyping rs153109, and suggests its utility as a candidate approach to evaluate IL-27 p28 polymorphisms as additional clinical predictors of response to therapies in HCV infected patients.
|
25236666 |
2014 |
Hepatitis C, Chronic
|
|
0.010 |
GeneticVariation
|
BEFREE |
This method has been applied in a preliminary study on patients with chronic hepatitis C to provide information for a standardized assay useful to genotyping of rs153109 SNPs of IL-27p28.
|
25236666 |
2014 |
Cryptorchidism
|
|
0.010 |
GeneticVariation
|
BEFREE |
The A allele and A/G genotype of rs153109 polymorphisms contribute to increase cryptorchidism susceptibility, and G allele and T/G genotype of rs17855750 also contribute to increase cryptorchidism susceptibility, which implies that these allele and genotypes may be risk factors for the development of cryptorchidism.
|
25988814 |
2016 |
Papillary thyroid carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the association between a potentially functional polymorphism (rs153109, -964A > G) in the promoter region of interleukin-27 (IL-27) gene and the risk of papillary thyroid cancer (PTC) in a Chinese population.
|
25994572 |
2015 |
Malignant neoplasm of urinary bladder
|
|
0.020 |
GeneticVariation
|
BEFREE |
Significantly increased risk for bladder cancer was associated with AG/GG genotypes of rs153109 (P = 0.029).
|
26014498 |
2015 |
Carcinoma of bladder
|
|
0.020 |
GeneticVariation
|
BEFREE |
Significantly increased risk for bladder cancer was associated with AG/GG genotypes of rs153109 (P = 0.029).
|
26014498 |
2015 |
Bladder Neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
Significantly increased risk for bladder cancer was associated with AG/GG genotypes of rs153109 (P = 0.029).
|
26014498 |
2015 |
Renal Cell Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present study provided evidence that rs153109 and rs17855750 were associated with increased risk for RCC, suggesting an important role IL-27 may play in nephrocarcinogenesis.
|
26161702 |
2015 |
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present study provided evidence that rs153109 and rs17855750 were associated with increased risk for RCC, suggesting an important role IL-27 may play in nephrocarcinogenesis.
|
26161702 |
2015 |
Malignant neoplasm of urinary bladder
|
|
0.020 |
GeneticVariation
|
BEFREE |
When a stratification analysis was performed by cancer type, we identified an increased susceptibility of bladder cancer in rs153109 polymorphism.
|
26303036 |
2015 |
Bladder Neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
When a stratification analysis was performed by cancer type, we identified an increased susceptibility of bladder cancer in rs153109 polymorphism.
|
26303036 |
2015 |
Carcinoma of bladder
|
|
0.020 |
GeneticVariation
|
BEFREE |
When a stratification analysis was performed by cancer type, we identified an increased susceptibility of bladder cancer in rs153109 polymorphism.
|
26303036 |
2015 |
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
However, no association between IL-27 rs153109 and rs181206 polymorphisms and cancer susceptibility was identified.
|
26303036 |
2015 |
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, no association between IL-27 rs153109 and rs181206 polymorphisms and cancer susceptibility was identified.
|
26303036 |
2015 |
Ulcerative Colitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Disease type-stratified subgroup analysis yielded increased risk of related diseases in IL-27 rs181206 T>C carriers in the allele model in immune thrombocytopenia (ITP), asthma, and esophageal cancer (EC) subgroups (ITP: OR=0.69, 95%CI=0.53~0.88, P=0.004; asthma: OR=0.60, 95%CI=0.41~0.89, P=0.010; EC: OR=0.79, 95%CI=0.64~0.97, P=0.026); and IL-27 rs153109 A>G polymorphism was remarkably associated with the increased risk of related diseases in the allele model in ovarian cancer (OC), systemic lupus erythematosus (SLE), tuberculosis (TB), ulcerative colitis (UC), and chronic obstructive pulmonary disease (COPD) subgroups (all P<0.05).
|
26950245 |
2016 |
Immune thrombocytopenic purpura
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results indicate that the genetic polymorphisms of IL-27 rs153109 and rs181206 may be involved in the progression of human cancers and diseases, especially of TB, UC, COPD, OC, and ITP.
|
26950245 |
2016 |
Lupus Erythematosus, Systemic
|
|
0.020 |
GeneticVariation
|
BEFREE |
Disease type-stratified subgroup analysis yielded increased risk of related diseases in IL-27 rs181206 T>C carriers in the allele model in immune thrombocytopenia (ITP), asthma, and esophageal cancer (EC) subgroups (ITP: OR=0.69, 95%CI=0.53~0.88, P=0.004; asthma: OR=0.60, 95%CI=0.41~0.89, P=0.010; EC: OR=0.79, 95%CI=0.64~0.97, P=0.026); and IL-27 rs153109 A>G polymorphism was remarkably associated with the increased risk of related diseases in the allele model in ovarian cancer (OC), systemic lupus erythematosus (SLE), tuberculosis (TB), ulcerative colitis (UC), and chronic obstructive pulmonary disease (COPD) subgroups (all P<0.05).
|
26950245 |
2016 |
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results indicate that the genetic polymorphisms of IL-27 rs153109 and rs181206 may be involved in the progression of human cancers and diseases, especially of TB, UC, COPD, OC, and ITP.
|
26950245 |
2016 |
Esophageal Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Disease type-stratified subgroup analysis yielded increased risk of related diseases in IL-27 rs181206 T>C carriers in the allele model in immune thrombocytopenia (ITP), asthma, and esophageal cancer (EC) subgroups (ITP: OR=0.69, 95%CI=0.53~0.88, P=0.004; asthma: OR=0.60, 95%CI=0.41~0.89, P=0.010; EC: OR=0.79, 95%CI=0.64~0.97, P=0.026); and IL-27 rs153109 A>G polymorphism was remarkably associated with the increased risk of related diseases in the allele model in ovarian cancer (OC), systemic lupus erythematosus (SLE), tuberculosis (TB), ulcerative colitis (UC), and chronic obstructive pulmonary disease (COPD) subgroups (all P<0.05).
|
26950245 |
2016 |