|
Alcoholic Intoxication, Chronic
|
|
0.040 |
GeneticVariation
|
BEFREE |
We have screened 200 Japanese workers and 105 Japanese patients with alcoholism for the mutation in the signal peptide of pre-pro-neuropeptide Y resulting in a substitution of proline for leucine at position 7.
|
11409703 |
2001 |
|
Alcoholic Intoxication, Chronic
|
|
0.040 |
GeneticVariation
|
BEFREE |
Recent studies have provided evidence for an association between a Leu7Pro polymorphism, as well as 2 promoter single nucleotide polymorphisms (SNPs) in the NPY gene (G-602T, T-399C) and alcohol dependence.
|
18241322 |
2008 |
|
Alcoholic Intoxication, Chronic
|
|
0.040 |
GeneticVariation
|
BEFREE |
NPY Leu7Pro and alcohol dependence in Finnish and Swedish populations.
|
12544000 |
2003 |
|
Alcoholic Intoxication, Chronic
|
|
0.040 |
GeneticVariation
|
BEFREE |
A functional neuropeptide Y Leu7Pro polymorphism associated with alcohol dependence in a large population sample from the United States.
|
12215082 |
2002 |
|
Anxiety
|
|
0.010 |
GeneticVariation
|
BEFREE |
Leu7Pro was analyzed in a large well-characterized longitudinal population-based sample of adult Swedes with data on life situation and life history, including 461 with depression diagnosis, 157 with anxiety diagnosis and 1514 healthy individuals with no symptom of psychopathology.
|
19264362 |
2009 |
|
Anxiety Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
Leu7Pro was analyzed in a large well-characterized longitudinal population-based sample of adult Swedes with data on life situation and life history, including 461 with depression diagnosis, 157 with anxiety diagnosis and 1514 healthy individuals with no symptom of psychopathology.
|
19264362 |
2009 |
|
Arteriosclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The results indicate significant associations between inflammatory cell activation in blood and vascular atherosclerosis in genetically prone subjects, and provide possible mechanistic information about the role of NPY and the Leu7Pro polymorphism in the development of atherosclerosis.
|
21746772 |
2011 |
|
Arteriosclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The leucine7 to proline7 (Leu7Pro) polymorphism in preproneuropeptide Y (preproNPY) has been associated with accelerated atherosclerosis and type II diabetes, both of which are obesity-related diseases.
|
18043699 |
2009 |
|
Arteriosclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
In this study, we investigated the role of two functional NPY polymorphisms, NPY-Leu7Pro (rs16139) and NPY-399C/T (rs16147) and obesity for the development of asthma as well as atherosclerosis in asthmatic and non-asthmatic subjects.
|
23122776 |
2012 |
|
Arteriosclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
A rather common leucine7-to-proline7 (Leu7Pro) polymorphism in the preproneuropeptide Y (prepro-NPY) gene signal peptide may be important in blood pressure regulation, cholesterol metabolism and the pathogenesis of atherosclerosis in humans.
|
11689216 |
2001 |
|
Asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study, we investigated the role of two functional NPY polymorphisms, NPY-Leu7Pro (rs16139) and NPY-399C/T (rs16147) and obesity for the development of asthma as well as atherosclerosis in asthmatic and non-asthmatic subjects.
|
23122776 |
2012 |
|
Atherosclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The leucine7 to proline7 (Leu7Pro) polymorphism in preproneuropeptide Y (preproNPY) has been associated with accelerated atherosclerosis and type II diabetes, both of which are obesity-related diseases.
|
18043699 |
2009 |
|
Atherosclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
A rather common leucine7-to-proline7 (Leu7Pro) polymorphism in the preproneuropeptide Y (prepro-NPY) gene signal peptide may be important in blood pressure regulation, cholesterol metabolism and the pathogenesis of atherosclerosis in humans.
|
11689216 |
2001 |
|
Atherosclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The results indicate significant associations between inflammatory cell activation in blood and vascular atherosclerosis in genetically prone subjects, and provide possible mechanistic information about the role of NPY and the Leu7Pro polymorphism in the development of atherosclerosis.
|
21746772 |
2011 |
|
Atherosclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
In this study, we investigated the role of two functional NPY polymorphisms, NPY-Leu7Pro (rs16139) and NPY-399C/T (rs16147) and obesity for the development of asthma as well as atherosclerosis in asthmatic and non-asthmatic subjects.
|
23122776 |
2012 |
|
Cardiovascular Diseases
|
|
0.030 |
GeneticVariation
|
BEFREE |
Therefore, we investigated the impact of the Leu7Pro polymorphism on diabetic nephropathy, cardiovascular risk factors, and cardiovascular disease in type 1 diabetic patients.
|
14747236 |
2004 |
|
Cardiovascular Diseases
|
|
0.030 |
GeneticVariation
|
BEFREE |
SNP association studies using p.L7P polymorphism suggest that this functional substitution may be a strong independent risk factor for various metabolic and cardiovascular diseases.
|
18499283 |
2008 |
|
Cardiovascular Diseases
|
|
0.030 |
GeneticVariation
|
BEFREE |
The Leu7Pro substitution has been linked to cardiovascular disease, but it is unknown whether the Pro7 allele is associated with increased or decreased risk of coronary heart disease (CHD).
|
18054939 |
2008 |
|
Carotid Atherosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Leucine 7 to proline 7 polymorphism in the neuropeptide Y gene is associated with enhanced carotid atherosclerosis in elderly patients with type 2 diabetes and control subjects.
|
10852461 |
2000 |
|
Complications of Diabetes Mellitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
Since no impact of preproNPY genotype on mean NPY or hormone levels were detected in subjects with type 2 diabetes, the mechanisms for the increased risk for diabetic complications in the subjects with the Leu7Pro polymorphism need to be further explored.
|
17516289 |
2007 |
|
Coronary Arteriosclerosis
|
|
0.050 |
GeneticVariation
|
BEFREE |
Leucine 7 to proline 7 polymorphism in the preproneuropeptide Y is associated with proteinuria, coronary heart disease, and glycemic control in type 1 diabetic patients.
|
14747236 |
2004 |
|
Coronary Arteriosclerosis
|
|
0.050 |
GeneticVariation
|
BEFREE |
The aim of the present study was to investigate the association of the Leu7Pro polymorphism with coronary atherosclerosis and its consequences.
|
18054939 |
2008 |
|
Coronary Arteriosclerosis
|
|
0.050 |
GeneticVariation
|
BEFREE |
Association of leucine 7 to proline 7 polymorphism in the preproneuropeptide Y with serum lipids in patients with coronary heart disease.
|
11914038 |
2002 |
|
Coronary Arteriosclerosis
|
|
0.050 |
GeneticVariation
|
BEFREE |
Neuropeptide Y Leu7Pro polymorphism associated with the metabolic syndrome and its features in patients with coronary artery disease.
|
22308535 |
2013 |
|
Coronary Arteriosclerosis
|
|
0.050 |
GeneticVariation
|
BEFREE |
High frequency of Neuropeptide Y Leu7Pro polymorphism in an Iranian population and its association with coronary artery disease.
|
22289186 |
2012 |