|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Leucine 7 to proline 7 polymorphism in the neuropeptide Y gene is associated with enhanced carotid atherosclerosis in elderly patients with type 2 diabetes and control subjects.
|
10852461 |
2000 |
|
Carotid Atherosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Leucine 7 to proline 7 polymorphism in the neuropeptide Y gene is associated with enhanced carotid atherosclerosis in elderly patients with type 2 diabetes and control subjects.
|
10852461 |
2000 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Leucine 7 to proline 7 polymorphism in the neuropeptide y gene is associated with retinopathy in type 2 diabetes.
|
10926322 |
2000 |
|
Retinal Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
Leucine 7 to proline 7 polymorphism in the neuropeptide y gene is associated with retinopathy in type 2 diabetes.
|
10926322 |
2000 |
|
Alcoholic Intoxication, Chronic
|
|
0.040 |
GeneticVariation
|
BEFREE |
We have screened 200 Japanese workers and 105 Japanese patients with alcoholism for the mutation in the signal peptide of pre-pro-neuropeptide Y resulting in a substitution of proline for leucine at position 7.
|
11409703 |
2001 |
|
Arteriosclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
A rather common leucine7-to-proline7 (Leu7Pro) polymorphism in the preproneuropeptide Y (prepro-NPY) gene signal peptide may be important in blood pressure regulation, cholesterol metabolism and the pathogenesis of atherosclerosis in humans.
|
11689216 |
2001 |
|
Atherosclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
A rather common leucine7-to-proline7 (Leu7Pro) polymorphism in the preproneuropeptide Y (prepro-NPY) gene signal peptide may be important in blood pressure regulation, cholesterol metabolism and the pathogenesis of atherosclerosis in humans.
|
11689216 |
2001 |
|
Coronary Arteriosclerosis
|
|
0.050 |
GeneticVariation
|
BEFREE |
Association of leucine 7 to proline 7 polymorphism in the preproneuropeptide Y with serum lipids in patients with coronary heart disease.
|
11914038 |
2002 |
|
Coronary heart disease
|
|
0.050 |
GeneticVariation
|
BEFREE |
Association of leucine 7 to proline 7 polymorphism in the preproneuropeptide Y with serum lipids in patients with coronary heart disease.
|
11914038 |
2002 |
|
Coronary Artery Disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
Association of leucine 7 to proline 7 polymorphism in the preproneuropeptide Y with serum lipids in patients with coronary heart disease.
|
11914038 |
2002 |
|
Alcoholic Intoxication, Chronic
|
|
0.040 |
GeneticVariation
|
BEFREE |
A functional neuropeptide Y Leu7Pro polymorphism associated with alcohol dependence in a large population sample from the United States.
|
12215082 |
2002 |
|
Alcoholic Intoxication, Chronic
|
|
0.040 |
GeneticVariation
|
BEFREE |
NPY Leu7Pro and alcohol dependence in Finnish and Swedish populations.
|
12544000 |
2003 |
|
Dyslipidemias
|
|
0.010 |
GeneticVariation
|
BEFREE |
The Leu7Pro polymorphism in the signal peptide of the preproneuropeptide Y (NPY) has been associated with dyslipidemias and free fatty acid (FFA) levels during exercise.
|
12759898 |
2003 |
|
Coronary Arteriosclerosis
|
|
0.050 |
GeneticVariation
|
BEFREE |
Leucine 7 to proline 7 polymorphism in the preproneuropeptide Y is associated with proteinuria, coronary heart disease, and glycemic control in type 1 diabetic patients.
|
14747236 |
2004 |
|
Coronary heart disease
|
|
0.050 |
GeneticVariation
|
BEFREE |
We conclude that the Leu7Pro polymorphism may contribute to the genetic susceptibility to diabetic nephropathy and CHD in type 1 diabetic patients, possibly by influencing glycemic control and triglycerides.
|
14747236 |
2004 |
|
Coronary Artery Disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
Leucine 7 to proline 7 polymorphism in the preproneuropeptide Y is associated with proteinuria, coronary heart disease, and glycemic control in type 1 diabetic patients.
|
14747236 |
2004 |
|
Cardiovascular Diseases
|
|
0.030 |
GeneticVariation
|
BEFREE |
Therefore, we investigated the impact of the Leu7Pro polymorphism on diabetic nephropathy, cardiovascular risk factors, and cardiovascular disease in type 1 diabetic patients.
|
14747236 |
2004 |
|
Diabetic Nephropathy
|
|
0.030 |
GeneticVariation
|
BEFREE |
We conclude that the Leu7Pro polymorphism may contribute to the genetic susceptibility to diabetic nephropathy and CHD in type 1 diabetic patients, possibly by influencing glycemic control and triglycerides.
|
14747236 |
2004 |
|
Diabetic Retinopathy
|
|
0.020 |
GeneticVariation
|
BEFREE |
The leucine 7 to proline 7 (Leu7Pro) polymorphism, located in the signal peptide part of the human preproneuropeptide Y, has been associated with serum lipid levels, intima-media thickness of the common carotid arteries, and diabetic retinopathy in type 2 diabetic patients.
|
14747236 |
2004 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present study thus provides the evidence that Leu7Pro polymorphism in the NPY gene is associated with IGT and T2DM in Swedish men, and indicates that the NPY gene variations contribute to development of T2DM.
|
15926114 |
2005 |
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present study thus provides the evidence that Leu7Pro polymorphism in the NPY gene is associated with IGT and T2DM in Swedish men, and indicates that the NPY gene variations contribute to development of T2DM.
|
15926114 |
2005 |
|
Obesity
|
|
0.050 |
GeneticVariation
|
BEFREE |
The consistent findings among men suggest that the NPY Leu7Pro polymorphism (or another linked marker) might be involved in the development of obesity at younger ages.
|
16568137 |
2006 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that the Leu7Pro polymorphism could be used to predict earlier onset of type 2 diabetes and retinopathy, and increased risk for diabetic nephropathy.
|
16705546 |
2006 |
|
Diabetic Nephropathy
|
|
0.030 |
GeneticVariation
|
BEFREE |
These results suggest that the Leu7Pro polymorphism could be used to predict earlier onset of type 2 diabetes and retinopathy, and increased risk for diabetic nephropathy.
|
16705546 |
2006 |
|
Diabetic Retinopathy
|
|
0.020 |
GeneticVariation
|
BEFREE |
The Leu7Pro polymorphism of neuropeptide Y is associated with younger age of onset of type 2 diabetes mellitus and increased risk for nephropathy in subjects with diabetic retinopathy.
|
16705546 |
2006 |