|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Both rs17782313 (near MC4R) and rs1421085 (FTO) polymorphisms have been consistently associated with increased risk of obesity and with body mass index (BMI) variation.
|
19153581 |
2009 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Women with extreme obesity carrying rs17782313 MC4R polymorphism present a higher pre-surgical BMI, are more unlikely to reach non-obesity BMI (<30 kg/m<sup>2</sup>) and tend to maintain a BMI > 35 kg/m<sup>2</sup> that characterize treatment failure.
|
28579220 |
2018 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
In case-control studies of obesity defined by BMI, the minor C-allele of rs17782313 was associated with overweight/obesity and obesity (odds ratio [OR] 1.09, P = 0.006 and OR 1.12, P = 0.003, respectively).
|
19073769 |
2009 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
To investigate the association between the fat mass and obesity related (FTO) gene rs9939609 and near melanocortin-4-receptor (MC4R) gene rs17782313 polymorphisms with obesity measures and metabolic parameters in urban and rural dwelling Sri Lankans.
|
26948330 |
2016 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our results suggested that FTO rs9939609, MC4R rs12970134, and MC4R rs17782313 are strongly associated with obesity.
|
30896429 |
2019 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Therefore, the present study aimed to examine the relationships between FTO rs9939609 and the MC4R rs17782313 with REE, leptin, ghrelin and thyrotropin levels in obe</span>se women.
|
24307561 |
2014 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our data support that the rs9939609 and rs17782313 are strongly associated with obesity and BMI.
|
21063808 |
2011 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
After age and sex adjustment and correction for multiple testing, the SNPs rs17782313, rs6265, and rs10938397 were associated with BMI (P = 1.0 × 10⁻⁵, 0.038, and 0.00093, respectively) and also obesity (P = 5.0 × 10⁻⁶, 0.043, and 0.00085, respectively) in the Chinese children.
|
20843981 |
2010 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
In our study, rs17782313 did not show significant association with either obesity or BMI in the Chinese Han population, but showed evidence for association with LDL-C (P ~ 0.003) and TC (P ~ 0.001).
|
22350153 |
2012 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recently a modest, but consistently, replicated association was demonstrated between obesity and the single-nucleotide polymorphism (SNP), rs17782313, 3' of the MC4R locus as a consequence of a meta-analysis of genome-wide association (GWA) studies of the disease in white populations.
|
19265794 |
2009 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
MC4R rs17782313 was associated with obesity and could confer a certain susceptibility to T2D that could be independent of its pro-obesity effect.
|
24151814 |
2014 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Analysis of MC4R rs17782313, POMC rs1042571, APOE-Hha1 and AGRP rs3412352 genetic variants with susceptibility to obesity risk in North Indians.
|
26226973 |
2016 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our findings indicated that rs17782313, rs543874, rs2241423 and rs11084753 were associated with the risk for children obesity in China, and interaction of genetic variants with diet behaviors on obesity.
|
25637721 |
2015 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
In the present study, we examined the association between variants in fat mass- and obesity-associated [rs9939609 (A/T)], melanocortin 4 receptor [rs17782313 (C/T), and rs12970134 (A/G)], SLC30A8 [rs13266634 (C/T)], and a member of the potassium voltage-gated channels [rs2237892(C/T)] genes in diabetes patients from Saudi Arabia.
|
25501231 |
2014 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Impact of the Polymorphism Near <i>MC4R</i> (rs17782313) on Obesity- and Metabolic-Related Traits in Women Participating in an Aerobic Training Program.
|
28828082 |
2017 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
In addition, BDNF rs6265 and MC4R rs17782313 showed gender-dependent associations with decreased risk of having low HDL-C in males and increased risk of having abdominal obesity in females, respectively.
|
31502573 |
2019 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Six other SNPs, rs2815752 (NEGR1), rs10938397 (GNPDA2), rs10838738 (MTCH2), rs7498665 (SH2B1), rs17782313 (MC4R) and rs11084753 (KCTD15), were not associated with obesity (P>0.05).
|
22083549 |
2012 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
The rs17782313 C allele is associated with eating behavior traits that may predispose obese children to increased energy intake and obesity.
|
27730429 |
2017 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
In sum, our data support the associations of variants rs17782313 and rs12970134 near MC4R with early onset obesity and increased insulin levels.
|
21372613 |
2011 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Genome-wide association studies have shown that variants near the melanocortin 4 receptor gene (MC4R) (rs17782313 and rs12970134) are associated with risk of obesity in Europeans.
|
22869321 |
2012 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
The common polymorphism rs17782313 lying 188 kb downstream of the MC4R gene has recently been found to be unequivocally associated with body mass index (BMI) and obesity risk in adults and children.
|
20215774 |
2010 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Risk alleles for two obesity SNPs were associated with colorectal cancer risk--KCTD15 rs29941 [odds ratio (OR) for C allele = 0.90, 95% confidence interval (CI) 0.83-0.98; p = 0.01] and MC4R rs17782313 (OR for C allele = 1.12, 95% CI 1.02-1.22; p = 0.02).
|
22511254 |
2012 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
In conclusion, we could replicate the previously reported association between rs17782313 and complex obesity.
|
21303735 |
2011 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Melanocortin-4 receptor polymorphism rs17782313: association with obesity and eating in the absence of hunger in Chilean children.
|
24139164 |
2014 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
We found correlation for two SNPs--rs11642015 and rs62048402 in the fat mass and obesity-associated protein (FTO) with obesity but no association was detected for rs17782313 located in the MC4R locus in these severely obese individuals.
|
24385306 |
2014 |