rs1799983, NOS3

N. diseases: 246
Disease: High altitude pulmonary edema ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
High altitude pulmonary edema
CUI: C0340100
Disease: High altitude pulmonary edema
0.050 GeneticVariation BEFREE The case-control distributions of genotype frequencies</span> and T allele </span>frequency of NOS3 G894T (Glu298Asp) polymorphism were significantly higher in the cases than controls, and the NOS3 G894T (Glu298Asp) SNP showed elevated HAPE risk under the dominant model (TT+GT vs. GG). 23603420 2013
High altitude pulmonary edema
CUI: C0340100
Disease: High altitude pulmonary edema
0.050 GeneticVariation BEFREE Association of endothelial nitric oxide synthase (eNOS) G894T polymorphism with high altitude pulmonary edema susceptibility: a meta-analysis. 22795910 2012
High altitude pulmonary edema
CUI: C0340100
Disease: High altitude pulmonary edema
0.050 GeneticVariation BEFREE The wild-type haplotypes G-b (G894T, 4b/4a), G-A (G894T, -922A/G), and G-b-A (G894T, 4b/4a, -922A/G) were significantly overrepresented in HAPE-r (p < 0.0001, p = 0.03, and p = 0.02, respectively). 17099031 2006
High altitude pulmonary edema
CUI: C0340100
Disease: High altitude pulmonary edema
0.050 GeneticVariation BEFREE NOS3 gene polymorphisms (G894T, T-786C, and CA-repeats > or =38) might be linked to decreased NO synthesis and increased susceptibility to HAPE, while the C242T polymorphism of the CYBA gene [encoding for the NAD(P)H oxidase subunit p22phox] may increase NO availability and thus convey resistance to HAPE. 14561241 2003
High altitude pulmonary edema
CUI: C0340100
Disease: High altitude pulmonary edema
0.050 GeneticVariation BEFREE The Asp allelic frequency of the Glu298Asp variant was 25.6% in the HAPE-s and 9.8% in the controls, which was significantly different between the two groups (P=0.0044). 12176955 2002