Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Prevalence of anti-HCV in post-screening participants with HFE p.C282Y homozygosity and chronic HCV infection in referred adults with HFE p.C282Y homozygosity in North America is similar to that of Control participants with HFE wt/wt and normal screening TS/SF.
|
31056361 |
2020 |
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
A very small proportion of patients infected with hepatitis B virus (HBV) or hepatitis C virus (HCV; 1.8% and none, respectively) were heterozygous for the C282Y mutation, that is, rates not statistically different from those observed in healthy control (2%, P > 0.05).
|
22012716 |
2011 |
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
To determine the prevalence of the HFE gene mutations p.Cys282Tyr (C282Y), p.His63Asp (H63D) and p.Ser65Cys (S65C), the p.Tyr250X (Y250X) mutation of the TFR2 gene, and HCV infection in patients with PCT in the Czech population, and to make comparison of the iron status among the respective genotypes.
|
18565178 |
2008 |
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C282Y mutation has a relevant role in Spanish patients with PCT not associated with HCV chronic infection.
|
17062032 |
2006 |
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Multivariate analysis showed that C282Y heterozygous males were 3.8-fold (95% CI=1.0-15.2) more likely to be HBV positive and that H63D heterozygous females were 6.0-fold (95% CI=1.2-113.8) more likely to be HCV positive than wild type subjects.
|
15894495 |
2005 |
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
C282Y or H63D heterozygosity is an independent risk factor for liver fibrosis and cirrhosis in HCV infected individuals.
|
12586300 |
2003 |
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
our results suggest that the C282Y mutation, but not the H63D mutation, of the HFE gene is frequently associated with stainable iron in the liver in HCV-related chronic hepatitis.
|
14972004 |
2003 |
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
C282Y mutations and HCV infection but not H63D or S65C mutations are PCT-triggering or associated factors in the south of France.
|
12673077 |
2003 |
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
By multivariate logistic regression analysis the odds ratio for the development of advanced fibrosis or cirrhosis (F2-F4) was 2.5 for HCV-infected patients carrying a heterozygous C282Y mutation and 4.8 for HCV-infected patients with C282Y/H63D and C282Y/S65C compound heterozygosity.
|
14557859 |
2003 |
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Cys282Tyr allele was significantly overrepresented in hepatitis C patients (0.12 v. 0.07, P < 0.05) and principally in patients with the Hp 2-1 and 2-2 phenotypes.
|
11564959 |
2001 |
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Liver and peripheral blood were studied in 37 C282Y homozygous HH patients; nine normal livers and 11 livers from patients with cirrhosis due to hepatitis C virus or alcoholic liver disease were also investigated.
|
11168438 |
2001 |
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Siderotic patients had the same geographic origin, serum and liver HCV RNA levels and H63D and C282Y mutations frequency as non-siderotic patients.
|
10568758 |
2000 |
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Hepatic damage was most marked in patients with the Cys282Tyr/Cys282Tyr genotype who had HCV and drank heavily.
|
10688809 |
2000 |
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study we analyzed the livers of 50 transplant patients with a diagnosis of either hepatitis C cirrhosis or cryptogenic cirrhosis for the prevalence of the more common C282Y mutation of the HFE gene and correlated the findings to hepatic iron concentration.
|
11079015 |
2000 |
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Porphyria cutanea tarda in Brazilian patients: association with hemochromatosis C282Y mutation and hepatitis C virus infection.
|
11151887 |
2000 |
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
The recent identification of 2 mutations in the HFE gene related to hereditary haemochromatosis (Cys282Tyr and His63Asp) provided an opportunity to test whether they are associated with hepatic iron accumulation and the activity and severity of liver disease in hepatitis C virus (HCV) infection.
|
10692680 |
2000 |
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the hepatic siderosis group, C282Y homozygotes had significantly higher hepatic iron and ferritin levels, a significantly lower prevalence of hepatitis C virus or alcoholic liver disease, but no significant difference in the saturation of serum transferrin.
|
9576576 |
1998 |