|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, in the stratified analysis by cancer type, an increased risk was identified in hepatocellular carcinoma and breast cancer in C282Y polymorphism, as well as pancreatic cancer in H63D polymorphism, whereas a decreased risk of colorectal cancer was identified in C282Y polymorphism.
|
26107216 |
2015 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
C282Y homozygosity is associated with increased risk of colorectal cancer and hepatocellular cancer in men.
|
23281741 |
2013 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We assessed the influence of Ala16Val-superoxide dismutase 2, Pro198Leu-glutathione peroxidase 1, and -463G/A-myeloperoxidase genotypes (high activity for the Ala, Pro, and G alleles, respectively) on the risks of cirrhosis and hepatocellular carcinoma (HCC) in patients homozygous for the C282Y-hemochromatosis (HFE) gene mutation.
|
20673159 |
2011 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two SNPs (rs1800562 of HFE and rs2279744 of MDM2) were associated with HCC with moderate epidemiological evidence and deserve further study and additional biological and clinical assessment.
|
21240526 |
2011 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between C282Y and H63D mutations of the HFE gene with hepatocellular carcinoma in European populations: a meta-analysis.
|
20196837 |
2010 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Liver iron overload and C282Y mutation are associated with a higher risk of HCC in patients with alcoholic but not HCV-related cirrhosis.
|
18061182 |
2008 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
On the contrary, HFE C282Y and SERPINA1 mutations do not contribute to hepatocellular carcinoma development.
|
18164971 |
2008 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this population, we found that only a very small proportion of homozygotes for the HFE C282Y mutation developed hepatocellular carcinoma.
|
15929796 |
2005 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C282Y heterozygous genotype is significantly more common in HCC patients and is associated with significantly increased intrahepatic iron deposition and systemic iron stores.
|
15017669 |
2003 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Hepatocellular carcinoma was estimated to occur in 2673 men in the cohort (1:374); 267 of these cases were in the subgroup of 5000 C282Y homozygotes (1:17).
|
12790309 |
2003 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Except for C282Y homozygotes, HFE gene mutations do not increase the risk to develop HCC in patients with cirrhosis.
|
12591066 |
2003 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
C282Y and H63D mutations do not appear to be associated with an increased risk of HCC in patients with cirrhosis.
|
12865278 |
2003 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The high frequency of heterozygosity for the C282Y mutation in patients with alcoholic cirrhosis plus hepatocellular carcinoma suggests that the presence of this mutation could be associated with an increased risk of developing hepatocellular carcinoma in these patients.
|
12003382 |
2002 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The prevalence of the C282Y mutation was significantly higher in patients with hepatocellular carcinoma than in normal controls (8.6% vs 1.6%, P < 0.03).
|
11500061 |
2001 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The presence of the 2 mutations associated with hereditary hemochromatosis (C282Y and H63D) was sought by restriction fragment length polymorphism in 61 cirrhotic patients (46 males and 15 females) who underwent resection for HCC at a single institution.
|
10918159 |
2000 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
A germline C282Y mutation was found in none of the hepatocellular carcinoma patients; the frequency of the H63D mutation was not increased, compared to the 130 controls.
|
10660482 |
2000 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In patients with HCC in NCL and iron overload, C28</span>2Y mutations are frequent (36.8% of cases) and significantly increased (p<0.009) compared to HCC in NCL without iron overload; these mutations are mostly heterozygous.
|
10845668 |
2000 |