rs1800588, ALDH1A2;LIPC

N. diseases: 16
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Triglycerides measurement
CUI: C0202236
Disease: Triglycerides measurement
0.800 GeneticVariation GWASCAT Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases. 29403010 2018
Serum total cholesterol measurement
CUI: C1445957
Disease: Serum total cholesterol measurement
0.800 GeneticVariation GWASCAT Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases. 29403010 2018
Triglycerides measurement
CUI: C0202236
Disease: Triglycerides measurement
0.800 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
Serum total cholesterol measurement
CUI: C1445957
Disease: Serum total cholesterol measurement
0.800 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
High density lipoprotein measurement
0.800 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
Triglycerides measurement
CUI: C0202236
Disease: Triglycerides measurement
0.800 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
High density lipoprotein measurement
0.800 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.720 GeneticVariation BEFREE The common C-480T polymorphism (rs1800588) of the hepatic lipase gene (LIPC) has been associated with high-density lipoprotein (HDL) cholesterol, atherosclerosis, and coronary artery disease. 19558527 2009
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.720 GeneticVariation BEFREE 557 men aged 45-74 with stable coronary artery disease and 560 paired controls were genotyped for rs1800588. 23874450 2013
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.720 GeneticVariation GWASDB Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. 21347282 2011
Serum albumin measurement
CUI: C0523465
Disease: Serum albumin measurement
0.700 GeneticVariation GWASDB Genome-wide association study identifies multiple loci influencing human serum metabolite levels. 22286219 2012
Serum HDL cholesterol measurement
CUI: C0428472
Disease: Serum HDL cholesterol measurement
0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.030 GeneticVariation BEFREE The common C-480T polymorphism (rs1800588) of the hepatic lipase gene (LIPC) has been associated with high-density lipoprotein (HDL) cholesterol, atherosclerosis, and coronary artery disease. 19558527 2009
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.030 GeneticVariation BEFREE A family-based quantitative transmission disequilibrium test (QTDT) revealed significant association between variant rs1800588 in LIPC and HDL-C in the GeneQuest population (P = 0.0067), which may account for the minor QTL on 15q22. 20075193 2010
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.030 GeneticVariation BEFREE 557 men aged 45-74 with stable coronary artery disease and 560 paired controls were genotyped for rs1800588. 23874450 2013
Coronary Arteriosclerosis
CUI: C0010054
Disease: Coronary Arteriosclerosis
0.020 GeneticVariation BEFREE 557 men aged 45-74 with stable coronary artery disease and 560 paired controls were genotyped for rs1800588. 23874450 2013
Coronary Arteriosclerosis
CUI: C0010054
Disease: Coronary Arteriosclerosis
0.020 GeneticVariation BEFREE The common C-480T polymorphism (rs1800588) of the hepatic lipase gene (LIPC) has been associated with high-density lipoprotein (HDL) cholesterol, atherosclerosis, and coronary artery disease. 19558527 2009
Dyslipidemias
CUI: C0242339
Disease: Dyslipidemias
0.010 GeneticVariation BEFREE We examined the influence of the promoter polymorphisms -250G/A (rs2070895) and -514C/T (rs1800588) in the human hepatic lipase (LIPC) gene on dyslipidemia and hypertensive disorders complicating pregnancy (HDCP) in a Chinese population. 25117371 2014
Fatty Liver
CUI: C0015695
Disease: Fatty Liver
0.010 GeneticVariation BEFREE The aim of the present study was to evaluate the role of the C-514T (rs1800588) gene polymorphism of the hepatic lipase (LIPC) as susceptibility marker for fatty liver in the Mexican population. 25550127 2015
Diabetes
CUI: C0011847
Disease: Diabetes
0.010 GeneticVariation BEFREE Only major allele carriers benefited from the higher-fat diet for HDL-C. Secondarily, we explored dietary fat quality and rs1800588 for HDL-C and triglycerides (TG) in a Boston Puerto Rican Health Study (BPRHS) subset matched for diabetes and obesity status (subset <i>n</i> = 384). 28939642 2017
Obesity
CUI: C0028754
Disease: Obesity
0.010 GeneticVariation BEFREE Only major allele carriers benefited from the higher-fat diet for HDL-C. Secondarily, we explored dietary fat quality and rs1800588 for HDL-C and triglycerides (TG) in a Boston Puerto Rican Health Study (BPRHS) subset matched for diabetes and obesity status (subset <i>n</i> = 384). 28939642 2017
Hypertensive disease
CUI: C0020538
Disease: Hypertensive disease
0.010 GeneticVariation BEFREE However, LIPC rs1800588 polymorphism was not associated with the susceptibility to hypertension. 30322388 2018
Steatohepatitis
CUI: C2711227
Disease: Steatohepatitis
0.010 GeneticVariation BEFREE The aim of the present study was to evaluate the role of the C-514T (rs1800588) gene polymorphism of the hepatic lipase (LIPC) as susceptibility marker for fatty liver in the Mexican population. 25550127 2015
Diabetes Mellitus
CUI: C0011849
Disease: Diabetes Mellitus
0.010 GeneticVariation BEFREE Only major allele carriers benefited from the higher-fat diet for HDL-C. Secondarily, we explored dietary fat quality and rs1800588 for HDL-C and triglycerides (TG) in a Boston Puerto Rican Health Study (BPRHS) subset matched for diabetes and obesity status (subset <i>n</i> = 384). 28939642 2017
Hypertriglyceridemia
CUI: C0020557
Disease: Hypertriglyceridemia
0.010 GeneticVariation BEFREE Among South Indian subjects without diabetes, the rs1800588 C/T (C-480T) and rs6074 C/A (Thr479Thr) variants of the HL gene are associated with hypertriglyceridemia and low HDL-C, respectively. 23550552 2013