<b>Results</b>: Three out of 10 eligible SNPs were shown to be associated with risk of ischemic stroke. rs1800947 in <i>CRP</i> gene (additive model: OR = 2.08, 95% CI: 1.00-4.23) and rs1169288 in <i>HNF1A</i> gene (additive model: OR = 1.45, 95% CI: 1.03-2.06) were associated with an increased risk of ischemic stroke. rs440446 in <i>APOE</i> gene (additive model: OR = 0.63, 95%CI: 0.44-0.88) was associated with a decreased risk of ischemic stroke.
A total of 1716 patients from western China with first-ever IS were genotyped for the CRP SNPs rs1130864 and rs1800947 using the ligation detection reaction method.
The rs1800947 SNP and the C-C-C haplotype in the CRP gene appear to be prognostic markers of ischemic stroke and this polymorphism could be a useful genetic marker.