|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
Combined effects of the C161T and Pro12Ala PPARγ2 gene variants with insulin resistance on metabolic syndrome: a case-control study of a central Tunisian population.
|
24243083 |
2014 |
|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the group of participants with PPARγ Pro12Ala or Ala12Ala genotypes, those with the LPL Pvu (-/+) or (+/+) genotype had greater odds for MetSy (odds ratio OR=5.98; 95% confidence interval CI: 1.46-24.47, p=0.013).
|
24200052 |
2014 |
|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study suggests that the PPARγ C1431T polymorphism is related to an increased risk of MetS in an Iranian population and interacts with the Pro12Ala polymorphism, further increasing the risk of MetS.
|
24464185 |
2014 |
|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
The frequency distribution of rare alleles for PPARα (L162V) and PPARγ (P12A and H449H) was compared using the chi square test in 363 HIV-1-infected patients classified according to the presence or absence of the metabolic syndrome after 48 months of follow-up on their first PI-containing regimen.
|
21877956 |
2012 |
|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
The influences of PPARγ (C1431T and Pro12Ala) and RBP4 (-803GA) polymorphisms on metabolic syndrome in HIV-infected patients receiving anti-retroviral therapy were examined in this study.
|
23145084 |
2012 |
|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
PPARγ Pro12Ala and ACE ID polymorphisms are associated with BMI and fat distribution, but not metabolic syndrome.
|
22168210 |
2011 |
|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
The PPARγ2 gene single nucleotide polymorphism (SNP) Pro12Ala has shown variable association with metabolic syndrome traits in healthy subjects.
|
21949049 |
2011 |
|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to evaluate the frequency of Pro12Ala PPARgamma polymorphism and its association with body mass index (BMI) and metabolic syndrome parameters in postmenopausal Polish women.
|
19609844 |
2009 |
|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
C1431T, but not Pro12Ala polymorphisms, are associated with MS in a Chinese population.
|
19237017 |
2009 |
|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
Pro12Ala polymorphism of the peroxisome proliferatoractivated receptor-gamma gene is associated with metabolic syndrome and surrogate measures of insulin resistance in healthy men: interaction with smoking status.
|
19745552 |
2009 |
|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of peroxisome proliferator-activated receptorgamma gene Pro12Ala and C161T polymorphisms with metabolic syndrome.
|
18362424 |
2008 |
|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data do not support a major role for the Pro12Ala variant of the PPARG gene in MetS and its individual components.
|
18959602 |
2008 |
|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Pro12Ala polymorphism of the PPAR gamma 2 gene influences sex hormone-binding globulin level and its relationship to the development of the metabolic syndrome in young Finnish men.
|
17322577 |
2006 |
|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the frequencies of two common polymorphisms of PPARgamma gene, exon 6 C-->T substitution and exon B Pro12Ala in healthy subjects and analyzed the correlations between the different genotypes and insulin resistance, metabolic syndrome and cardiovascular risk factors.
|
16314192 |
2006 |
|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Pro12Ala PPARG sequence variant together with a non-E3/E3 APOE genotype is associated with a high risk for postprandial hypertriglyceridemia in patients with the metabolic syndrome, indicating a close association between these genes and the regulation of lipoproteinase clearance.
|
16916989 |
2006 |
|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further analyses stratified on the 1431C>T single nucleotide polymorphism (SNP) indicated that the rare alleles of the P2 -689C>T and Pro12Ala SNPs were associated with an increased risk of the metabolic syndrome when combined to the 1431CC genotype.
|
16186413 |
2005 |
|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our objective was to search for differences in genotypes of peroxisome proliferator-activated receptor gamma (PPARgamma) (Pro12 Ala) and its coactivator PGC-1alpha (Gly482 Ser) in adolescents harboring features of metabolic syndrome.
|
16216916 |
2005 |
|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that the PPAR-gamma P12A polymorphism can modulate the association between dietary fat intake and components of the metabolic syndrome.
|
12630956 |
2003 |
|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
To investigate the role of the Pro12Ala peroxisome proliferator-activated receptor (PPAR) gamma-2 polymorphism in the susceptibility to the insulin resistance syndrome and its metabolic complications in a population-based nationwide multicenter study in Spain.
|
12370112 |
2002 |
|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
Comment: studies of the Pro12Ala polymorphism of the PPAR-gamma gene in the Danish MONICA cohort: homozygosity of the Ala allele confers a decreased risk of the insulin resistance syndrome.
|
12161548 |
2002 |
|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
To investigate in a population-based sample of Caucasians the relation of the Pro12Ala polymorphism with plasma concentrations of FFAs and other markers of lipid and glucose metabolism described as components of the insulin resistance syndrome.
|
12354130 |
2002 |
|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
We confirm an association of the P12A variant in traits commonly ascribed to the insulin resistance syndrome, but not with direct measures of insulin sensitivity.
|
11158005 |
2001 |