rs1990622, None

N. diseases: 16
Disease: Frontotemporal dementia ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Frontotemporal dementia
CUI: C0338451
Disease: Frontotemporal dementia
0.040 GeneticVariation BEFREE Recent studies found that two polymorphisms (rs363371 and rs363324) in VMAT2 might be a risk factor for Parkinson's disease (PD) in Caucasians, while the two other variants (rs1990622 and rs3173615) in TMEM106B increased the risk for frontotemporal dementia (FTD). 28477711 2017
Frontotemporal dementia
CUI: C0338451
Disease: Frontotemporal dementia
0.040 GeneticVariation BEFREE Association of TMEM106B rs1990622 marker and frontotemporal dementia: evidence for a recessive effect and meta-analysis. 25096617 2015
Frontotemporal dementia
CUI: C0338451
Disease: Frontotemporal dementia
0.040 GeneticVariation BEFREE Intriguingly, the genotype that confers increased risk for developing FTLD-TDP (major, or T, allele of rs1990622) is associated with later age at onset and death in C9orf72 expansion carriers, providing an example of sign epistasis in human neurodegenerative disease. 24442578 2014
Frontotemporal dementia
CUI: C0338451
Disease: Frontotemporal dementia
0.040 GeneticVariation BEFREE The association replicated in 89 FTLD-TDP cases (rs1990622; P = 2 x 10(-4)). 20154673 2010