|
Colorectal Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
The aim of the present study is to genotype the MDR1 2677G>T (rs2032582) and 3435C>T (rs1045642) polymorphism in patients with colorectal cancer and controls and to identify a possible association between individual genetic variation and susceptibility to colorectal cancer.
|
17674045 |
2008 |
|
Colorectal Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
We observed that the ABCB1 C3435T and G2677T/A variants as well as the 3435T-1236T-2677T haplotype significantly increased the risk of CRC.
|
23746184 |
2013 |
|
Colorectal Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
In particular, carriers of the T/T genotype in exon 12 (1236 C-->T) SNP and the T/T genotype in exon 21 (2677G-->T) SNP were most significantly associated with a higher risk for developing MSI-H CRC compared to controls (P=0.01, OR=3.182 and P=0.005, OR=3.594, respectively).
|
18474294 |
2008 |
|
Colorectal Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
Differences in ABCB1 (1236C>T) and ABCB1 (2677G>T/A) genotypes and T(1236) allele distribution between investigated populations indicate significant impact of these SNPs on risk of development of colorectal cancer.
|
19415305 |
2009 |
|
Colorectal Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
Compared with the ABCB1 gene SNPs rs1045642, rs2032582 or rs3789243 alone, combined haplotypes of several SNPs might be a better marker to determine the genetic influence on the susceptibility to colorectal cancer among Caucasians.
|
23279665 |
2013 |
|
Colorectal Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
To analyse the single-nucleotide polymorphisms (SNPs): ABCB1(1236C>T), ABCB1(2677G>T/A), ABCB1(3435C>T) and haplotypes in the ABCB1/MDR1 gene, which could contribute to genetic risk of colorectal cancer (CRC).
|
20533057 |
2010 |
|
Neutropenia
|
|
0.050 |
GeneticVariation
|
BEFREE |
In toxicity, the 2677G/T or A was associated with grade 4 neutropenia.
|
17534875 |
2007 |
|
Leukopenia
|
|
0.050 |
GeneticVariation
|
BEFREE |
Delayed time to neutropenia recovery was observed with ABCB1 rs2032582 variant (p = .047).
|
27701910 |
2017 |
|
Leukopenia
|
|
0.050 |
GeneticVariation
|
BEFREE |
On evaluating higher order gene-gene interaction models by MDR analysis, CYP3A5*3; ABCB11236C>T and ABCB1 2677G>T/A; ABCB1 3435C>T and CYP1B1*3 showed significant association with treatment response, grade 2-4 anemia and dose delay/reduction due to neutropenia (P=0.024, P=0.004, P=0.026), respectively.
|
24704000 |
2014 |
|
Leukopenia
|
|
0.050 |
GeneticVariation
|
BEFREE |
The multivariate logistic regression analysis revealed that the ABCB1 2677G>T/A polymorphism was a strong predictor of grade 3 or greater neutropenia (odds ratio: 3.76; 95% confidence interval: 1.44-9.81; p = 0.007).
|
25989890 |
2015 |
|
Neutropenia
|
|
0.050 |
GeneticVariation
|
BEFREE |
On evaluating higher order gene-gene interaction models by MDR analysis, CYP3A5*3; ABCB11236C>T and ABCB1 2677G>T/A; ABCB1 3435C>T and CYP1B1*3 showed significant association with treatment response, grade 2-4 anemia and dose delay/reduction due to neutropenia (P=0.024, P=0.004, P=0.026), respectively.
|
24704000 |
2014 |
|
Neutropenia
|
|
0.050 |
GeneticVariation
|
BEFREE |
Delayed time to neutropenia recovery was observed with ABCB1 rs2032582 variant (p = .047).
|
27701910 |
2017 |
|
Neutropenia
|
|
0.050 |
GeneticVariation
|
BEFREE |
The multivariate logistic regression analysis revealed that the ABCB1 2677G>T/A polymorphism was a strong predictor of grade 3 or greater neutropenia (odds ratio: 3.76; 95% confidence interval: 1.44-9.81; p = 0.007).
|
25989890 |
2015 |
|
Leukopenia
|
|
0.050 |
GeneticVariation
|
BEFREE |
In toxicity, the 2677G/T or A was associated with grade 4 neutropenia.
|
17534875 |
2007 |
|
Neutropenia
|
|
0.050 |
GeneticVariation
|
BEFREE |
Meta-analysis showed an decreased risk of irinotecan-induced neutropenia in patients expressing ABCB1 2677G>T/G (odds ratio [OR]: 0.24; 95% CI: 0.1-0.59; p = 0.002) but increased risk for ABCC2 3972T>T (OR: 1.67; 95% CI: 1.01-2.74; p = 0.04).
|
27269636 |
2016 |
|
Leukopenia
|
|
0.050 |
GeneticVariation
|
BEFREE |
Meta-analysis showed an decreased risk of irinotecan-induced neutropenia in patients expressing ABCB1 2677G>T/G (odds ratio [OR]: 0.24; 95% CI: 0.1-0.59; p = 0.002) but increased risk for ABCC2 3972T>T (OR: 1.67; 95% CI: 1.01-2.74; p = 0.04).
|
27269636 |
2016 |
|
Diffuse Large B-Cell Lymphoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our findings demonstrate that G, GT at locus G2677T/A, and TT at locus C3435T might contribute to the susceptibility to DLBCL, as well as haplotype of T-G-T, G-T in 2677-3435 and diplotype of 2677GT/3435TT, while AT at locus G2677T/A might be a protective genotype.
|
26211578 |
2015 |
|
Malignant neoplasm of colon and/or rectum
|
|
0.040 |
GeneticVariation
|
BEFREE |
Compared with the ABCB1 gene SNPs rs1045642, rs2032582 or rs3789243 alone, combined haplotypes of several SNPs might be a better marker to determine the genetic influence on the susceptibility to colorectal cancer among Caucasians.
|
23279665 |
2013 |
|
Breast Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
These results suggest that ABCB1 gene C3435T, G2677T/A variations and haplotype 3435T-1236T-2677T relate to the risk and clinical outcomes of breast carcinoma and may function as candidate molecular markers of anthracycline chemosensitivity in breast carcinoma.
|
22526155 |
2012 |
|
Myeloid Leukemia, Chronic
|
|
0.040 |
GeneticVariation
|
BEFREE |
Three single-nucleotide polymorphisms (C1236T, G2677T/A, C3435T) and/or mRNA expression changes of ABCB1 gene were demonstrated to be associated with inter-individual variability of imatinib response in CML patients.
|
28836054 |
2017 |
|
Neoplasms
|
|
0.040 |
GeneticVariation
|
BEFREE |
Significant associations of rs2032582 SNP with tumor size, negative HER-2/neu status, and family history of breast carcinoma were found.
|
23093106 |
2012 |
|
Myeloid Leukemia, Chronic
|
|
0.040 |
GeneticVariation
|
BEFREE |
We therefore studied three polymorphisms (C1236T, G2677T and C3435T) in the human multidrug-resistance gene (MDR1) in 86 patients with chronic myeloid leukaemia treated with imatinib.
|
27294449 |
2016 |
|
Neoplasms
|
|
0.040 |
GeneticVariation
|
BEFREE |
The G2677T and C3435T polymorphisms were studied and immunohistochemical analysis of the tumor and adjacent normal tissue was performed.
|
19192650 |
2009 |
|
Drug Resistant Epilepsy
|
|
0.040 |
GeneticVariation
|
BEFREE |
G2677T/A polymorphism of MDR1 may play a significant role in the development of DRE in the Polish patients.
|
28608314 |
2017 |
|
Diffuse Large B-Cell Lymphoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
These results suggest that the MDR1 T-129C, G2677T/A and C3435T polymorphisms are associated with risk of and survival in DLBCL, although the p-values are not as strong after Bonferroni correction.
|
23088763 |
2013 |