|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our findings show that a common polymorphism on chromosome 4q25 (rs2200733) is an independent predictor of AF recurrence after DCCV and point to a potential role of stratification by genotype.
|
23428961 |
2013 |
|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
The SNPs at the PITX2 and ZFHX3 loci, but not the KCNN3 locus, were significantly associated with AF (PITX2/rs6843082_G: odds ratio 3.41, 95% CI 2.55 to 4.55, P=1.32×10(-16); PITX2/rs2200733_T: odds ratio 2.05, 95% CI 1.66 to 2.53, P=2.20×10(-11); ZFHX3/rs2106261_A: odds ratio 2.33, 95% CI 1.87 to 2.91, P=3.75×10(-14); KCNN3/rs13376333_T: odds ratio 1.74, 95% CI 0.93 to 3.25, P=0.085).
|
26272656 |
2015 |
|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
These results derived from a sample of the Italian population agree with previously reported findings from an Icelandic study, which also found that the minor allele rs2200733 was associated with AF/AFL disease.
|
18931155 |
2008 |
|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
Among GWAS loci for AF, only three were replicated in the Chinese Han population, including SNP rs2106261 (G/A substitution) in ZFHX3, rs2200733 (C/T substitution) near PITX2c, and rs3807989 (A/G substitution) in CAV1.
|
26267381 |
2015 |
|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
Variants rs2200733 and rs7193343 are associated with a higher risk of atrial fibrillation.
|
25262128 |
2014 |
|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
Polymorphisms in PITX2 (rs2200733) and IL6 (rs1800795) are associated with postoperative atrial fibrillation in adults but have not been studied in CHD.
|
29800783 |
2018 |
|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our findings suggest that the rs2200733 polymorphism may hold promise as an objectively measured patient characteristic that can be used as a clinical tool for selecting patients for AF ablation.
|
23178686 |
2013 |
|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
Both rs2200733 and rs10033464 were also associated with long-term A</span>F (hazard ratio 1.32, 95% CI 1.05 to 1.67, and hazard ratio 1.28, 95% CI 1.00 to 1.66, respectively).
|
21414601 |
2011 |
|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
In total, our meta-analysis found that rs2200733 and rs10033464 on chromosome 4q25 (near PITX2) were associated with the risk of AF recurrence.
|
31169720 |
2019 |
|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate potential relations between rs2200733 versus clinical and electrocardiographic traits in a cohort of patients with early-onset AF who lack traditional risk factors.
|
21481830 |
2011 |
|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
In genetic association analyses, unstratified and stratified according to age of onset of AF and unaffected age >50 years, there was a highly statistically significant association between the presence of both common (rs2200733 and rs10033464) and rare variants and AF (unstratified p = 1 × 10(-8), stratified [age of onset <50 years and unaffected age >50 years] p = 7.6 × 10(-5)) (unstratified p < 0.0001, stratified [age of onset <50 years and unaffected age >50 years] p < 0.0001).
|
22818067 |
2012 |
|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
The previously reported SNP, rs2200733, was most significantly associated with AF (minor allele odds ratio 1.80, 95% confidence interval 1.50 to 2.15, P=1.2 x 10(-20)) in the discovery sample.
|
20733104 |
2010 |
|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
We aimed to assess whether SNPs previously associated with lone AF (rs2200733, rs13376333, rs3807989, and rs11047543) are also linked to P-wave abnormalities.
|
31152482 |
2019 |
|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
Among the 3 genetic loci most strongly associated with AF, the chromosome 4q25 SNP rs2200733 is significantly associated with recurrence of atrial arrhythmias after catheter ablation for AF.
|
25684755 |
2015 |
|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
The non-coding SNPs rs2200733 and rs10033464 are strongly associated with AF in four cohorts of European descent.
|
19141561 |
2009 |
|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
These findings suggest that the causal mechanism associated with rs2200733 is germane to both AF and Afl.
|
24237655 |
2014 |
|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
The SNP rs2200733 on chromosome 4q25 is a risk factor for CE stroke related to AF only.
|
21574119 |
2011 |
|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
We found that a common 4q25 AF susceptibility allele (rs2200733) is associated with PR interval prolongation in patients with lone and typical AF and controls with no AF.
|
24161141 |
2014 |
|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
Association with postoperative AF were measured and replicated for rs2200733 and rs13143308 in the validation cohort.
|
20031626 |
2009 |
|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
We analyzed the single nucleotide polymorphism (SNP) rs2200733 for the lone AF patients and compared them to a control group of 176 age matched healthy individuals.
|
21793630 |
2011 |
|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms in the chromosomal regions 4q25 (rs2200733) and 16q22 (rs2106261) associated with AF in genome-wide association studies were genotyped.
|
23132824 |
2013 |
|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
rs2200733 risk allele at the 4q25 predicted impaired clinical response to catheter ablation for AF in Chinese Han population.
|
27843048 |
2017 |
|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our results suggest that SNP rs2200733 confers a significant risk of AF in the Greek population, providing further support to the previously reported association between AF and rs2200733 polymorphism on chromosome 4q25.
|
26021244 |
2016 |
|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
BEFREE |
We discovered that variants previously shown to associate with atrial fibrillation (AF), rs2200733 and rs10033464, significantly associated with IS, with the strongest risk for CES.
|
18991354 |
2008 |
|
Atrial Fibrillation
|
|
0.900 |
GeneticVariation
|
GWASCAT |
A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke.
|
19597491 |
2009 |