|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further studies will be necessary to confirm the role of SNP 276G>T and 45T>G in the development of CAD.
|
16926524 |
2006 |
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
The risk of PCOS, hyperandrogenism in patients with PCOS and low serum adiponectin levels cannot be directly attributed to T45G adiponectin gene polymorphisms in exon 2, rather these polymorphisms may be associated with insulin resistance and hyperinsulinemia in PCOS.
|
20388053 |
2010 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs2241766/rs3774261 haplotype was also associated with obesity (nominal p = 0.004).
|
19573164 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings suggest that the adiponectin 45T/G polymorphism is associated with diabetic cardiovascular complication in type 2 diabetes.
|
29686595 |
2018 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The objective was to examine the association of two SNPs (45T/G and 276G/T) with coronary artery disease in a Tunisian population.
|
21738048 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
The two SNPs (45T-->G and 276G-->T) were chosen because of their association with type 2 diabetes in Japanese.
|
12086965 |
2002 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
The T45G and G276T of the adiponectin gene may not be an important determinant of Type 2 diabetes or insulin resistance in Korean subjects.
|
15842511 |
2005 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thus, our results demonstrated that, adiponectin SNP 45T/G, rather than SNP 276G/T, is more associated with risk of T2DM in obese individuals.
|
19929719 |
2009 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs2241766 polymorphism is found to be associated with a significant increase in CAD risk in Caucasian and genotyping method (PCR-RFLP) subgroups.
|
28881706 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs2241766T>G SNP of adiponectin gene is a risk factor for the development of T2DM in Iraqi population and directs the changes of serum lipid concentrations as well as insulin resistance.
|
29627525 |
2018 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found that the SNPs +45T>G (rs2241766), -4034A>C (rs822395), and -11391G>A (rs17300539) were linked to CAD development.
|
28617663 |
2017 |
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Several studies suggested an association between two single nucleotide polymorphisms (T45G and G276T) of the ADIPOQ gene that encodes for the hormone adiponectin and PCOS susceptibility.
|
31122534 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
The presence of +45T>G (rs2241766), +276G>T (rs1501299) and -11391G>A (rs17300539) do not appear to influence the development of type 2 diabetes.
|
21638131 |
2011 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Based on the relevant studies, it was determined that the risk of CAD was not associated with rs2241766 in any genetic model.
|
22386722 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
None of the other 10 SNPs were associated with T2DM in this study, although rs2241766 and rs1501299 were reported to be associated with T2DM in previous Chinese studies.
|
19631916 |
2009 |
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, we failed to find significant overtransmission of the other SNP, rs2241766, from parents to PCOS offspring.
|
24559720 |
2014 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The +45T >G polymorphism (rs2241766) of ADIPOQ was genotyped in 600 patients with angiographically diagnosed CAD and in 718 controls.
|
19661719 |
2009 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs2241766 and rs1501299 polymorphisms were associated with CAD.
|
22459242 |
2012 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results of this meta-analysis suggest that the ADIPOQ-rs2241766 G/T polymorphism might be associated with obesity in Chinese studies but not in non-Chinese studies in adults.
|
24740426 |
2014 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Better-designed studies that consider confounding factors and assess larger sample sizes with a focus on ADIPOQ-rs2241766G/T polymorphisms and obesity are required in the future.
|
24740426 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs266729 C allele and the rare minor alleles of rs2241766 and rs2082940 were associated with an increased adjusted hazard ratio of developing T2DM.
|
21219602 |
2011 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Previous findings that the ADIPOQ 45T-->G variant contributes to overall fatness and abdominal obesity are confirmed.
|
17209173 |
2007 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We recruited in total 594 subjects; 462 patients with angiographically confirmed coronary artery disease (CAD) and 132 controls matched for age and gender. rs2241766 and rs1501299 were genotyped by polymerase chain reaction and restriction endonuclease digestion.
|
23041095 |
2013 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition to these factors, metabolic syndrome may also be related to genetic factors, the ADIPOQ + 45T> G polymorphism has been associated with serum adiponectin levels, insulin sensitivity, and obesity, which affects adiponectin levels act as protective factor for cardiovascular disease.
|
29313754 |
2019 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The T45G polymorphism in the ADIPOQ gene and hypoadiponectinemia were associated with CAD in our T2D subjects of predominantly African background.
|
19960000 |
2010 |