|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Adiponectin rs2241766T/G and rs17300593G/A rather than rs1501299G/T and rs266729C/G polymorphisms were associated with the risk of DN in T2DM, especially in the Caucasian population.
|
24825737 |
2015 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
LEP rs7799039, LEPR rs1137101, and ADIPOQ rs2241766 and 1501299 Polymorphisms Are Associated With Obesity and Chemotherapy Response in Mexican Women With Breast Cancer.
|
28416193 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Varied association of ADIPOQ genotypes with T2DM was seen according to the genetic model used: rs17300539 and rs266729 were significantly associated with T2DM under the three models, while rs16861194 was association with T2DM under additive and dominant models, and rs822396, rs2241766, and rs1063538 were associated with T2DM under the dominant models only.
|
22497971 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this case-control study, the associations of rs2241766 T/G of ADIPOQ, rs9289231 T/G of KALRN, and rs9939609 A/T of FTO polymorphisms with genetic susceptibility to CAD in type 2 diabetic (T2D) patients were investigated.
|
27218147 |
2016 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Associations between 45T/G polymorphism of the adiponectin gene and plasma adiponectin levels with type 2 diabetes.
|
17973869 |
2007 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The net effects of T45G polymorphism on the MAO phenotype may be achieved by changes in the adiponectin oligomer ratio and glucose levels.
|
27236826 |
2019 |
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Haplotype TGTG from adiponectin gene variants 45T/G and 276G/T is related to susceptibility to PCOS, and might be associated with increased blood pressure in PCOS.
|
23685884 |
2014 |
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings indicated that rs1501299 and rs2241766 polymorphisms might serve as genetic biomarkers of PCOS in certain ethnicities.
|
30509295 |
2018 |
|
Colorectal Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
After adjusting for factors such as colorectal cancer family history, body-mass index (BMI), daily sedentary time, weekly red meat intake frequency, as well regular tea drinking, conditional logistic regression analysis indicated that rs2241766 TG+GG carriers had a higher risk of colorectal cancer than TT carriers (OR=1.433, 95% CI: 1.014-1.985); rs1501299 GT+TT carriers had a lower risk of colorectal cancer than GG carriers (OR=0.723, 95% CI: 0.531-0.902).
|
25489716 |
2015 |
|
Colorectal Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
Using rs2241766 as an instrument in Mendelian randomization analysis, an increment of 1 mg/L in circulating adiponectin was significantly associated with a 43-50% reduced risk for lung cancer, but with a 20-40% increased risk of colorectal cancer, respectively.
|
25273172 |
2015 |
|
Colorectal Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
This meta-analysis indicated that adiponectin rs2241766T/G rather than rs1501299G/T, rs266729C/G, rs822395A/C and rs822396A/G polymorphism was associated with the risk of colorectal cancer.
|
23869187 |
2013 |
|
Colorectal Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
In conclusion, the results showed that the ADIPOQ rs2241766 TG+GG genotype increased CRC risk.
|
23826253 |
2013 |
|
Colorectal Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
ADIPOQ rs2241766, ADIPOQ rs1501299 and CAPN-10 rs3792267 are significantly associated with CRC risk and the combination of the three polymorphisms and red meat affect CRC risk.
|
26203767 |
2015 |
|
Colorectal Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
With a hospital-based case-control study of 341 cases and 727 controls, the associations between the common variants on ADIPOQ (rs266729, rs822395, rs2241766 and rs1501299) and ADIPOR1 (rs1342387 and rs12733285) and CRC susceptibility were evaluated.
|
25516230 |
2014 |
|
Colorectal Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
ADIPOQ SNPs rs2241766 T/G and rs 1501299 G/T have a population-specific correlation with risk of CRC.
|
27704292 |
2017 |
|
Colorectal Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
Seven studies with 2,414 cases and 2,796 controls together did not show any significant association between SNP rs2241766</span> and CRC risk.
|
24293390 |
2014 |
|
Colorectal Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
Results of the current meta-analysis revealed that the rs2241766 T>G single-nucleotide polymorphisms (SNP) increase the risk of CRC; rs1501299 G>T under dominant model was associated with increased risk of CRC; and rs266729 C>G SNP under allele model conferred an increased risk of CRC.
|
26329379 |
2015 |
|
Metabolic Syndrome X
|
|
0.080 |
GeneticVariation
|
BEFREE |
G allele of ADIPOQ rs2241766 increases the risk of MS.
|
27554120 |
2016 |
|
Cardiovascular Diseases
|
|
0.080 |
GeneticVariation
|
BEFREE |
A significant association between rs2241766 in the adiponectin gene and CVD was established by the meta-analysis.
|
23972466 |
2014 |
|
Metabolic Syndrome X
|
|
0.080 |
GeneticVariation
|
BEFREE |
Aim of the study was to evaluate the prevalence of metabolic symptoms in patients with PA compared to controls and the prevalence of two single nucleotide polymorphisms (SNPs), T45G and G276T, in the adiponectin gene and their relationship to metabolic syndrome (MS).
|
23590605 |
2013 |
|
Hypertensive disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
Haplotype TGTG from adiponectin gene variants 45T/G and 276G/T is related to susceptibility to PCOS, and might be associated with increased blood pressure in PCOS.
|
23685884 |
2014 |
|
Hypertensive disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
We analyzed data from the Academia Sinica Collaborative Study on Hypertension Genetics in Taiwanese subjects to compare rs2241766 between YOHs with and without RH (≤50 years of age).
|
30529101 |
2019 |
|
Cardiovascular Diseases
|
|
0.080 |
GeneticVariation
|
BEFREE |
The present meta-analysis showed that the associations between rs2241766, rs1501299 and rs266729 in the ADIPOQ and CVD were significant but weak.
|
22639977 |
2012 |
|
Metabolic Syndrome X
|
|
0.080 |
GeneticVariation
|
BEFREE |
We conclude that the relationship between the habitual consumption of certain food groups and ADIPOQ indicates the need for further studies to develop a better understanding of this relationship; however, there was no association between the ADIPOQ + 45T> G gene polymorphism and metabolic syndrome in the group of elderly studied.
|
29313754 |
2019 |
|
Hypertensive disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
Our findings suggested that in spite of the nonsignificant association between ADIPOQ T45G or G276T polymorphism and hypertension, the heterozygous mutation of G276T was observed to account for increased levels of circulating adiponectin and blood pressure, especially in hypertensive patients.
|
28099908 |
2017 |