rs2333227, MPO

N. diseases: 15
Disease: Tumor Cell Invasion ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Tumor Cell Invasion
CUI: C1269955
Disease: Tumor Cell Invasion
0.010 GeneticVariation BEFREE Colorectal cancer cells with the rs2333227 TT genotype exhibited enhanced proliferation, migration, and invasion capacity <i>in vitro</i> and <i>in vivo</i> Mechanistically, we found that <i>MPO</i> SNP rs2333227 C to T mutation altered the binding affinity of the transcription factors AP-2α to the rs2333227 mutation region, sequentially enhancing expression levels of <i>MPO</i> and activating further IL23A-MMP9 axis-mediated oncogenic signaling. 29540402 2018