|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We examined the association of polymorphisms in XRCC1 (codon 194 Arg-->Trp and codon 399 Arg-->Gln) and breast cancer in the Carolina Breast Cancer Study, a population-based case-control study in North Carolina.
|
11303590 |
2001 |
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
We examined the association of polymorphisms in XRCC1 (codon 194 Arg-->Trp and codon 399 Arg-->Gln) and breast cancer in the Carolina Breast Cancer Study, a population-based case-control study in North Carolina.
|
11303590 |
2001 |
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
In our association study between three amino acid substitution polymorphisms of XRCC1 (Arg194Trp, Arg280His, and Arg399Gln) and the risk of gastric cancer in the Korean population, none of the polymorphisms were associated with increased risk of gastric cancer.
|
12359351 |
2002 |
|
Stomach Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In our association study between three amino acid substitution polymorphisms of XRCC1 (Arg194Trp, Arg280His, and Arg399Gln) and the risk of gastric cancer in the Korean population, none of the polymorphisms were associated with increased risk of gastric cancer.
|
12359351 |
2002 |
|
Skin carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
The XRCC1 Arg399Gln polymorphism, sunburn, and non-melanoma skin cancer: evidence of gene-environment interaction.
|
11782372 |
2002 |
|
Squamous cell carcinoma of esophagus
|
|
0.030 |
GeneticVariation
|
BEFREE |
However, the XRCC1 Arg399Gln polymorphism was not significantly associated with risk of ESCC, with the adjusted OR being 0.87 (95% CI 0.55-1.37).
|
12124811 |
2002 |
|
Adenocarcinoma of pancreas
|
|
0.010 |
GeneticVariation
|
BEFREE |
A population-based study of the Arg399Gln polymorphism in X-ray repair cross- complementing group 1 (XRCC1) and risk of pancreatic adenocarcinoma.
|
12183419 |
2002 |
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
No association between XRCC1 Arg399Gln Dgenotype and breast cancer risk was observed.
|
14652281 |
2003 |
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
The overall results of the study suggest that Arg399Gln polymorphism of the XRCC1 gene alone may not play a substantial role in the risk of breast cancer among Chinese women.
|
14693738 |
2003 |
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
The study goal was to examine the association of three polymorphisms in the XRCC1 gene (Arg194Trp, Arg280His, and Arg399Gln) involved in repairing DNA damage produced by ionizing radiation, a known breast cancer (BC) risk factor, with BC incidence and the possibility of developing an adverse radiotherapy response.
|
14652276 |
2003 |
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
This report provides resequencing data confirming the existence of commonly occurring SNPs, including Arg194Trp and Arg399Gln, and briefly summarizes epidemiological and functional relevance to cancer and other age-related diseases.
|
12618003 |
2003 |
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We used a case-control study design (162 cases and 302 controls) to test the association between three amino acid substitution variants of DNA repair genes (XRCC1 Arg194Trp, XRCC1 Arg399Gln, and XRCC3 Thr241Met) and breast cancer susceptibility.
|
12565173 |
2003 |
|
Primary malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this case-control study of 1091 Caucasian lung cancer patients and 1240 controls, we explored the gene-environment interactions between the XRCC1 Arg399Gln polymorphism, alone or in combination with the two ERCC2 polymorphisms, and cumulative smoking exposure in the development of lung cancer.
|
12692111 |
2003 |
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this case-control study of 1091 Caucasian lung cancer patients and 1240 controls, we explored the gene-environment interactions between the XRCC1 Arg399Gln polymorphism, alone or in combination with the two ERCC2 polymorphisms, and cumulative smoking exposure in the development of lung cancer.
|
12692111 |
2003 |
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
We used a case-control study design (162 cases and 302 controls) to test the association between three amino acid substitution variants of DNA repair genes (XRCC1 Arg194Trp, XRCC1 Arg399Gln, and XRCC3 Thr241Met) and breast cancer susceptibility.
|
12565173 |
2003 |
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The study goal was to examine the association of three polymorphisms in the XRCC1 gene (Arg194Trp, Arg280His, and Arg399Gln) involved in repairing DNA damage produced by ionizing radiation, a known breast cancer (BC) risk factor, with BC incidence and the possibility of developing an adverse radiotherapy response.
|
14652276 |
2003 |
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this case-control study of 1091 Caucasian lung cancer patients and 1240 controls, we explored the gene-environment interactions between the XRCC1 Arg399Gln polymorphism, alone or in combination with the two ERCC2 polymorphisms, and cumulative smoking exposure in the development of lung cancer.
|
12692111 |
2003 |
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The overall results of the study suggest that Arg399Gln polymorphism of the XRCC1 gene alone may not play a substantial role in the risk of breast cancer among Chinese women.
|
14693738 |
2003 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
This report provides resequencing data confirming the existence of commonly occurring SNPs, including Arg194Trp and Arg399Gln, and briefly summarizes epidemiological and functional relevance to cancer and other age-related diseases.
|
12618003 |
2003 |
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
No association between XRCC1 Arg399Gln Dgenotype and breast cancer risk was observed.
|
14652281 |
2003 |
|
Laryngeal Squamous Cell Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Eighty-eight patients with laryngeal SCC and 178 randomly selected healthy blood donors from the same Caucasian population (Porto, Northern Portugal) were analysed for CYP1A1 (MspI and NcoI) and XRCC1 (Arg194Trp and Arg399Gln) polymorphisms, using PCR-RFLP techniques.
|
14639127 |
2003 |
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the present study, we investigated the effect of two XRCC1 polymorphisms, Arg194Trp and Arg399Gln, on breast cancer risk in a case- control study involving Turkish breast cancer patients and healthy women.
|
15665590 |
2004 |
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that APE1 Asp148Glu and XRCC1 Arg399Gln polymorphisms might modify the risk of lung cancer attributable to cigarette smoking exposure.
|
15044328 |
2004 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Growing evidence suggests that the polymorphism of DNA base excision repair gene XRCC1 Arg399Gln is associated with altered DNA repair proficiency and subsequent cancer susceptibility; however, no evidence is available for malignant lymphoma.
|
15104288 |
2004 |
|
Primary malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that APE1 Asp148Glu and XRCC1 Arg399Gln polymorphisms might modify the risk of lung cancer attributable to cigarette smoking exposure.
|
15044328 |
2004 |