rs25487, XRCC1

N. diseases: 205
Disease: Kidney Failure, Chronic ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Kidney Failure, Chronic
CUI: C0022661
Disease: Kidney Failure, Chronic
0.020 GeneticVariation BEFREE Haplotypes association showed that association of Gln allele of XRCC1 Arg399Gln polymorphism with the Asn allele of XPDAsp312Asn polymorphism (p = 0.004) or Gln allele of XRCC1 Arg399Gln polymorphism with the Gln allele of XPD Lys751Gln polymorphism (p = 0.003) was highly significantly associated with the development of ESRD. 25310768 2015
Kidney Failure, Chronic
CUI: C0022661
Disease: Kidney Failure, Chronic
0.020 GeneticVariation BEFREE This is the first report showing an association between DNA repair gene polymorphisms and ESRD development, and suggests that XRCC1 Arg399Gln polymorphism may confer increased risk for the development of the disease. 22302399 2012