rs268, LPL

N. diseases: 41
Disease: Dyslipidemias ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Dyslipidemias
CUI: C0242339
Disease: Dyslipidemias
0.030 GeneticVariation BEFREE This meta-analysis indicates that the Asn291Ser variant in the LPL gene is a risk factor for dyslipidemia, characterized by hypertriglyceridemia and low HDL-C levels. 16741292 2006
Dyslipidemias
CUI: C0242339
Disease: Dyslipidemias
0.030 GeneticVariation BEFREE There was a significant interaction between Asn291Ser and insulin resistance in normoglycaemic subjects, indicating that dyslipidaemia is more severe in Asn/ Ser carriers with reduced insulin sensitivity. 11073182 2000
Dyslipidemias
CUI: C0242339
Disease: Dyslipidemias
0.030 GeneticVariation BEFREE Carriers of N291S or D9N missense mutations in the lipoprotein lipase (LPL) gene exhibit reductions in LPL activity and are predisposed to dyslipidemia and cardiovascular disease. 10636447 1999