Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
Individual SNP-based analyses revealed that the rare allele of the IL1A SNP rs2856836, Ex7-592Tright curved arrow C, was strongly associated with breast cancer risk (FDR-adjusted p-value, 1df=0.0027, 2df=0.0162).
|
20127018 |
2010 |
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Individual SNP-based analyses revealed that the rare allele of the IL1A SNP rs2856836, Ex7-592Tright curved arrow C, was strongly associated with breast cancer risk (FDR-adjusted p-value, 1df=0.0027, 2df=0.0162).
|
20127018 |
2010 |
Ankylosing spondylitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The SNP rs2856836 in IL1A was significantly associated with spondyloarthritis (p=0.009) and AS (p=0.010) in the family study.
|
22312160 |
2012 |
Spondylarthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The SNP rs2856836 in IL1A was significantly associated with spondyloarthritis (p=0.009) and AS (p=0.010) in the family study.
|
22312160 |
2012 |
Endometriosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
The four common variants (rs17561, rs1304037, rs2856836 and rs3783553) in IL1A were significantly associated with endometriosis (P=0.0024, 0.0024, 0.0014 and 0.0061, respectively).
|
23635948 |
2013 |
Endometriosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Recently, two small Japanese studies reported eight SNPs (rs6542095, rs11677416, rs3783550, rs3783525, rs3783553, rs2856836, rs1304037 and rs17561) at the IL1A gene locus as suggestively associated with endometriosis risk.
|
25336714 |
2015 |
Stomach Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Compared with the wild heterozygote genotype, the variant heterozygote genotype of rs2472188 and rs2515401 in IL-1F5 polymorphisms were significantly associated with increased GC risks (ORadjusted [95%CI]: 1.51[1.15-1.99] and ORadjusted[95%CI]: 1.36[1.04-1.76]), but no significant differences existed in other 7 IL-1 family SNPs (rs2856836 in IL-1A, rs3732131 in IL-1R1, rs1135354 and rs3771157 in IL-18RA, rs3180235, rs957201 and rs2515402 in IL-1F5) with GC.
|
26632693 |
2015 |
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
Compared with the wild heterozygote genotype, the variant heterozygote genotype of rs2472188 and rs2515401 in IL-1F5 polymorphisms were significantly associated with increased GC risks (ORadjusted [95%CI]: 1.51[1.15-1.99] and ORadjusted[95%CI]: 1.36[1.04-1.76]), but no significant differences existed in other 7 IL-1 family SNPs (rs2856836 in IL-1A, rs3732131 in IL-1R1, rs1135354 and rs3771157 in IL-18RA, rs3180235, rs957201 and rs2515402 in IL-1F5) with GC.
|
26632693 |
2015 |
Lumbar disc disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs2856836, rs1304037, rs17561 and rs1800587 variants of the IL1A gene were associated with the severity of LDD and Modic changes.
|
28081267 |
2017 |
Lhermitte-Duclos disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs2856836, rs1304037, rs17561 and rs1800587 variants of the IL1A gene were associated with the severity of LDD and Modic changes.
|
28081267 |
2017 |
Endometriosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
The <i>IL1A</i> rs2856836 T/C SNP was associated with susceptibility to endometriosis and the rs2856836 C allele may increase the risk of endometriosis in Iranian women.
|
31248297 |
2020 |