Here we generated a novel, viable, and fertile mouse (Cx26<sup>CK14-S17F/+</sup>) with the keratitis-ichthyosis-deafness mutant (Cx26S17F) driven by the cytokeratin 14 promoter.
Here we generated a novel, viable, and fertile mouse (Cx26<sup>CK14-S17F/+</sup>) with the keratitis-ichthyosis-deafness mutant (Cx26S17F) driven by the cytokeratin 14 promoter.
Here we generated a novel, viable, and fertile mouse (Cx26<sup>CK14-S17F/+</sup>) with the keratitis-ichthyosis-deafness mutant (Cx26S17F) driven by the cytokeratin 14 promoter.
Interestingly, this asparagine is near two of the residues mutated in Keratitis-like ichthyosis deafness (KID) syndrome (G12R and S17F), yet the phenotype associated with N14K strongly differs from the KID phenotype.
Interestingly, this asparagine is near two of the residues mutated in Keratitis-like ichthyosis deafness (KID) syndrome (G12R and S17F), yet the phenotype associated with N14K strongly differs from the KID phenotype.