|
Malignant neoplasm of colon and/or rectum
|
|
0.010 |
GeneticVariation
|
BEFREE |
P53-R273H mutation enhances colorectal cancer stemness through regulating specific lncRNAs.
|
31455383 |
2019 |
|
Squamous cell carcinoma of esophagus
|
|
0.010 |
GeneticVariation
|
BEFREE |
Mutant TP53 G245C and R273H promote cellular malignancy in esophageal squamous cell carcinoma.
|
30126368 |
2018 |
|
Squamous cell carcinoma of penis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Biallelic GOF mutations (p.R273H and p.R273C) were identified in a 19-year-old male with glioblastoma (allele frequencies 94% and 48%) and a 54-year-old with pT3 penile squamous cell carcinoma (allele frequencies 19% and 27%).
|
29666004 |
2018 |
|
Tumor Initiation
|
|
0.010 |
GeneticVariation
|
BEFREE |
We show that p53-R273H-mediated DLX2 repression leads to upregulation of Neuropilin-2 (NRP2), a multifunctional co-receptor involved in tumor initiation, growth, survival and metastasis. p53-R273H-induced cell mobility is effectively suppressed by DLX2 expression.
|
28796261 |
2017 |
|
Prostate carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Targeting CD24 provides a strategy to enhance mutant p53-restoring therapies, especially in patients with TP53(R273H) prostate cancer.
|
26712693 |
2016 |
|
Malignant neoplasm of prostate
|
|
0.010 |
GeneticVariation
|
BEFREE |
Silencing of CD24 enhanced restoration of PRIMA-1-induced mutant p53 in endogenous TP53(P223L/V274F) DU145 cells and in PC3 cells transfected with TP53(R273H) CONCLUSIONS: In human prostate cancers, there is CD24-dependent inactivation of mutant p53.
|
26712693 |
2016 |
|
Triple-Negative Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study supports using the biological markers of high expression of mtp53 R273H or R248Q as additional diagnostics for TNBC resistant subtypes often found in the AA community.
|
26703669 |
2015 |
|
Triple Negative Breast Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study supports using the biological markers of high expression of mtp53 R273H or R248Q as additional diagnostics for TNBC resistant subtypes often found in the AA community.
|
26703669 |
2015 |
|
Carcinoma, Spindle-Cell
|
|
0.010 |
GeneticVariation
|
BEFREE |
Combining p53(R273H) with KRAS(G12V) activation caused transformation of MOE into high-grade sarcomatoid carcinoma when xenografted into nude mice.
|
25810107 |
2015 |
|
Lichen Sclerosus et Atrophicus
|
|
0.010 |
GeneticVariation
|
BEFREE |
In matched samples, immunohistochemistry evaluation of p53 protein expression revealed the presence of epidermal p53 clones in LS whose presence and number significantly correlated with the presence of TP53 C742T and G818C mutations.
|
17554370 |
2007 |
|
Endometrial Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
p53 dominant-negative mutant R273H promotes invasion and migration of human endometrial cancer HHUA cells.
|
17636407 |
2007 |
|
Diffuse Large B-Cell Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
A single missense mutation at codon 157 (Val to Phe) in exon 5 and at codon 273 (Arg to Pro) in exon 8 was found respectively in 2 DLBLs and in one peripheral T-cell lymphoma (unspecified).
|
17609875 |
2007 |
|
Peripheral T-Cell Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
A single missense mutation at codon 157 (Val to Phe) in exon 5 and at codon 273 (Arg to Pro) in exon 8 was found respectively in 2 DLBLs and in one peripheral T-cell lymphoma (unspecified).
|
17609875 |
2007 |
|
Skin Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Here, we show, using conditional mouse technology, that epithelium-specific heterozygous expression of mutant p53 (i.e., the p53.R270H mutation that is equivalent to the human hotspot R273H) results in an increased incidence of spontaneous and UVB-induced skin tumors.
|
17510390 |
2007 |
|
Malignant neoplasm of endometrium
|
|
0.010 |
GeneticVariation
|
BEFREE |
p53 dominant-negative mutant R273H promotes invasion and migration of human endometrial cancer HHUA cells.
|
17636407 |
2007 |
|
Mammary gland tumor
|
|
0.010 |
GeneticVariation
|
BEFREE |
Heterozygous p53(R270H/+)WAPCre mice (with mammary gland-specific expression of the p53.R270H mutation, equivalent to human R273H, at physiologic levels) develop mammary tumors at high frequency, indicating that the R270H mutation predisposes for mammary gland tumor development and acts in a dominant-negative manner in early stages of tumorigenesis.
|
16166291 |
2005 |
|
Carcinoma of bladder
|
|
0.010 |
GeneticVariation
|
BEFREE |
Various human p53 mutants (V143A, V173L, H179Q, N247I and R273H) were introduced to the TCC-SUP bladder carcinoma cell line to establish stable transfectants.
|
11435891 |
2001 |
|
Caffeine related disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
To investigate whether CAF radiosensitization correlated with lack of wild-type (wt) p53, we studied transfected derivatives of an adenoma-derived cell line (PC/AA/C1), in which the endogenous wt p53 activity was disrupted by the expression of a dominant negative (273Arg-->His) p53 mutant protein (designated AA/273p53/B).
|
9815821 |
1997 |
|
Xeroderma Pigmentosum, Complementation Group D
|
|
0.010 |
GeneticVariation
|
BEFREE |
We also found that wild-type, but not Arg273His mutant p53 inhibits XPD (Rad3) and XPB DNA helicase activities.
|
7663514 |
1995 |
|
Leukemia, T-Cell
|
|
0.010 |
GeneticVariation
|
BEFREE |
One patient had no p53 mutation in his leukemic cells during chronic phase of ATL, but had a homozygous point mutation at codon 273 (Arg to His) when he progressed to acute ATL.
|
1730092 |
1992 |
|
Adult T-Cell Lymphoma/Leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
One patient had no p53 mutation in his leukemic cells during chronic phase of ATL, but had a homozygous point mutation at codon 273 (Arg to His) when he progressed to acute ATL.
|
1730092 |
1992 |
|
Secondary Neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
Together, these results reveal an important role for DLX2-NRP2 in p53-R273H</span>-induced cell mobility and tumor metastasis.
|
28796261 |
2017 |
|
Neoplasm Metastasis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Together, these results reveal an important role for DLX2-NRP2 in p53-R273H</span>-induced cell mobility and tumor metastasis.
|
28796261 |
2017 |
|
Osteosarcoma of bone
|
|
0.020 |
GeneticVariation
|
BEFREE |
Some of the genetic changes identified were in tumor suppressor genes previously identified as altered in osteosarcoma: p53 (arginine→histidine at codon 273 [R273H], R→cysteine at codon 723 [R273C], and tyrosine→C at codon 163 [Y163C]) and retinoblastoma 1 (RB1) (glutamic acid→* at codon 137 [E137*]).
|
22006429 |
2012 |
|
Childhood Osteosarcoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Some of the genetic changes identified were in tumor suppressor genes previously identified as altered in osteosarcoma: p53 (arginine→histidine at codon 273 [R273H], R→cysteine at codon 723 [R273C], and tyrosine→C at codon 163 [Y163C]) and retinoblastoma 1 (RB1) (glutamic acid→* at codon 137 [E137*]).
|
22006429 |
2012 |