|
Allergic rhinitis (disorder)
|
|
0.010 |
GeneticVariation
|
BEFREE |
For CTLA-4, AA genotype and A allele in rs3087243 and rs231725 were increased in AR with asthma group while in AR group, AA genotype and A allele in rs231725 were obviously decreased.
|
27917628 |
2016 |
|
Ankylosing spondylitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of the HLA-B27 antigen and the CTLA4 gene CT60/rs3087243 polymorphism with ankylosing spondylitis in Algerian population: A case-control study.
|
29675891 |
2018 |
|
Appendicitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Associations with appendicitis were found for SNPs IL-13 rs1800925 with odds ratio (OR) 6.02 (95% CI 1.52-23.78) for T/T versus C/C + T/T, for IL-17 rs2275913 with OR 2.38 (CI 1.24-4.57) for A/A vs G/G + GA, for CCL22 rs223888 with OR 0.12 (0.02-0.90), and for A/A vs G/G + GA. Signs of effect modification of age for the association with appendicitis were found for IL-13 rs1800925 and CTLA4 rs3087243.
|
31845023 |
2020 |
|
Asthma
|
|
0.020 |
GeneticVariation
|
BEFREE |
For CTLA-4, AA genotype and A allele in rs3087243 and rs231725 were increased in AR with asthma group while in AR group, AA genotype and A allele in rs231725 were obviously decreased.
|
27917628 |
2016 |
|
Asthma
|
|
0.020 |
GeneticVariation
|
BEFREE |
We genotyped CTLA4 CT60 (rs3087243) functional single nucleotide polymorphism (SNP) in children with asthma and in healthy controls and correlated the genotype data with asthma clinical data, including treatment response with inhaled corticosteroids measured by forced expiratory volume in the first second (FEV(1)).
|
19895365 |
2010 |
|
Autoantibody measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
|
21829393 |
2011 |
|
AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 2
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
AUTOIMMUNE DISEASE, SUSCEPTIBILITY TO, 6
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Autoimmune Diseases
|
|
0.810 |
GeneticVariation
|
GWASDB |
Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.
|
21383967 |
2011 |
|
Autoimmune Diseases
|
|
0.810 |
GeneticVariation
|
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Autoimmune Diseases
|
|
0.810 |
GeneticVariation
|
BEFREE |
We have evaluated functional polymorphism (rs3087243; in literature known also as CTLA4 CT60) in the cytotoxic T lymphocyte antigen 4 (CTLA4) gene, previously associated with several autoimmune diseases, for potential association with inflammatory bowel diseases (IBD).
|
20491567 |
2010 |
|
Autoimmune thyroid disease (AITD)
|
|
0.030 |
GeneticVariation
|
BEFREE |
With respect to the rs3087243 (+6230G>A) polymorphism of CTLA4, the first sister had type 1 diabetes and AITD and had the GG genotype, whereas the second and third sisters, who had type 1 diabetes without AITD, had the AG genotype.
|
19506323 |
2009 |
|
Autoimmune thyroid disease (AITD)
|
|
0.030 |
GeneticVariation
|
BEFREE |
Taken together, our study suggested that the CT60 polymorphism (rs3087243) in CTLA-4 gene might confer susceptibility to the AITDs (GD/HT).
|
24697361 |
2014 |
|
Autoimmune thyroid disease (AITD)
|
|
0.030 |
GeneticVariation
|
BEFREE |
Furthermore, a joint analysis, with the INS and CTLA4 SNPs, revealed that CTLA4 rs3087243, ERBB3 rs2292399, and CLEC16A rs2903692, but not INS rs689, were significant risk factors for the cooccurrence of AITD in Japanese T1D.
|
18940880 |
2009 |
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Also, the +6230G>A (rs3087243) polymorphism reduced breast cancer risk especially in the Chinese population under homozygous and recessive models.
|
28097051 |
2017 |
|
CELIAC DISEASE, SUSCEPTIBILITY TO, 3 (finding)
|
|
0.700 |
SusceptibilityMutation
|
CLINVAR |
|
|
|
|
Childhood Osteosarcoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The current study evaluated the association of four CTLA-4 gene mutations, -1661A/G (rs4553808), -318C/T (rs5742909), +49G/A (rs231775), and CT60A/G (rs3087243), with osteosarcoma in the Chinese population.
|
21612409 |
2011 |
|
Chronic kidney disease stage 5
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present study was designed to investigate the impact of CTLA-4+49 A>G (rs231775), -318 C>T (rs5742909), -658 C>T (rs11571317), -1147 C>T (rs16840252), -1661 A>G (rs4553808), +6230 A>G (rs3087243) SNPs, and microsatellite (AT)n repeat polymorphism among end-stage renal disease (ESRD), acute allograft rejection (AR), and delayed graft function (DGF) cases.
|
24313821 |
2014 |
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The AG + AA genotypes of CTLA-4/rs3087243 statistically and antagonistically interacted with soybeans, pork and alcohol intake and were associated with CRC risk.
|
25604582 |
2015 |
|
Cytomegalovirus Infections
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the present study, we have made an attempt to investigate the impact of CTLA4 single nucleotide polymorphisms (SNPs) (rs231775, rs5742909, rs11571317, rs16840252, rs4553808, rs3087243) and dinucleotide (AT)n repeat polymorphism on the incidence of symptomatic HCMV infection (disease) among 270 renal allograft recipients.
|
25356901 |
2015 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.860 |
GeneticVariation
|
BEFREE |
Here, we analysed the effect of T1D-associated major HLA class II haplotypes and seven single nucleotide polymorphisms in six non-HLA genes [INS (rs689), PTPN22 (rs2476601), IL2RA (rs12722495 and rs2104286), PTPN2 (rs45450798), CTLA4 (rs3087243) and ERBB3 (rs2292239)] on peripheral blood Treg frequencies.
|
31808541 |
2019 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.860 |
GeneticVariation
|
GWASCAT |
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.
|
18978792 |
2008 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.860 |
GeneticVariation
|
BEFREE |
With respect to the rs3087243 (+6230G>A) polymorphism of CTLA4, the first sister had type 1 diabetes and AITD and had the GG genotype, whereas the second and third sisters, who had type 1 diabetes without AITD, had the AG genotype.
|
19506323 |
2009 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.860 |
GeneticVariation
|
GWASCAT |
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
|
19430480 |
2009 |