|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
A common missense variant in the LRRK2 gene, Gly2385Arg, associated with Parkinson's disease risk in Taiwan.
|
16633828 |
2006 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our study lends support to the contention that the Gly2385Arg is a common risk factor for PD in the Chinese population.
|
17019612 |
2007 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
These data suggest that the G2385R variant contributes significantly to the etiology of PD in ethnic Han Chinese individuals.
|
17187665 |
2006 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Lrrk2 G2385R is an ancestral risk factor for Parkinson's disease in Asia.
|
17222580 |
2007 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Leucine-rich repeat kinase 2 G2385R variant is a risk factor for Parkinson disease in Asian population.
|
17314670 |
2007 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
While the most common mutation G2019S and the risk variant G2385R were not found in our samples, we detected a novel missense mutation (S973N) in a patient with familial, late-onset and dopa-responsive PD.
|
17523199 |
2007 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The frequency of the heterozygous Gly2385Arg genotype was not significantly different in PD compared with controls (1.2% vs. 0.8%, odds ratio = 2.83, 95% CI 0.40, 20.2, P = 0.3).
|
17659642 |
2007 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
A common LRRK2 Gly2385Arg variant has been widely shown to be associated with a twofold increased risk of PD in various Asian populations.
|
17720280 |
2009 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We conducted an analysis of independent studies involving 2205 PD and 1817 controls and found the average carrier rate of G2385R variant to be about 9% in PD and 4% in controls (p < 0.001; odds ratio: 2.27; 95% confidence interval: 1.78-2.9).
|
17868389 |
2007 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our study indicates that the LRRK2 Gly2385Arg variant is a potential ethnic-specific genetic risk factor of Parkinson's disease within Chinese Han ethnicity.
|
17960808 |
2007 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
LRRK2 Gly2385Arg variant is a risk factor of Parkinson's disease among Han-Chinese from mainland China.
|
18201193 |
2008 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
A common LRRK2 Gly2385Arg variant has been widely shown to be associated with a two fold increased risk of PD in various Asian populations.
|
18316234 |
2008 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We conclude that the Gly2385Arg variant is not associated with primary dystonia in Taiwan, supporting the specificity of the association between this variant and PD.
|
18450497 |
2008 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The frequency of LRRK2 Gly2385Arg mutation in Hong Kong Chinese with early-onset (age < or =45 years) Parkinson's disease was identified and compared with late-onset patients (age >50 years) and controls.
|
18523722 |
2008 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The clinical phenotypes and [(18)F]-dopa PET findings for subjects with R1441H or G2385R resembled those of patients with idiopathic PD; however, their lymphoblastoid cell lines showed increased apoptosis following exposure to a proteosome inhibitor.
|
18523869 |
2008 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recently, G2385R substitution in LRRK2 has been determined as a susceptibility allele in Asian PD.
|
18704525 |
2008 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
G2385R was highly associated with PD under a dominant model in our dataset (adjusted OR, 1.83; 95% CI, 1.31-2.54; P = 3.3 x 10(-4)) and similar results were seen in the meta-analysis (summary OR assuming fixed effects, 2.55; 95% CI, 2.10-3.10).
|
19343804 |
2009 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Two polymorphic variants found almost exclusively among Asians (G2385R and R1628P) have been shown to increase the Parkinson's disease risk by approximately two-fold.
|
19804413 |
2009 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
This study supports that the LRRK2 G2385R variant may be a genetic risk factor for sporadic PD in the Korean population.
|
19854095 |
2010 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
In addition, we also explored the potential relationship between GBA L444P mutation and LRRK2 G2385R and R1628P variants in patients with PD.But no association was found, either.
|
20004703 |
2010 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We and others found two polymorphic LRRK2 (leucine-rich repeat kinase 2) variants (rs34778348:G>A; p.G2385R and rs33949390:G>C; p.R1628P) associated with Parkinson disease (PD) among Chinese patients, but the common worldwide rs34637584:G>A; p.G2019S mutation, was absent.
|
20186690 |
2010 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The present study confirms that the LRRK2 Gly2385Arg variant is a risk factor for sporadic PD.
|
20673920 |
2010 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
In addition, the frequency of p.G2385R was also higher in sPD than in controls, although not significant (allele frequency, 3.4 vs 2.1%) (χ(2)=0.76, P=0.38).
|
21796139 |
2011 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
LRRK2 p.G2385R variant (odds ratio [OR] = 3.2; 95% confidence interval [CI] = 1.96-5.15, p < 0.0001), not BDNF p.V66M alone significantly increased the risk of PD.
|
21924942 |
2012 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.
|
22438815 |
2012 |