Waldenstrom Macroglobulinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
<i>Results</i>: MYD88 L265P mutations were detected in 22 of 29 samples from 14 patients with diffuse large B-cell lymphomas and one patient with lymphoplasmacytoid lymphoma.
|
31603365 |
2019 |
Waldenstrom Macroglobulinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Detection of MYD88 L265P mutation by next-generation deep sequencing in peripheral blood mononuclear cells of Waldenström's macroglobulinemia and IgM monoclonal gammopathy of undetermined significance.
|
31483817 |
2019 |
Waldenstrom Macroglobulinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The diagnosis of WM is established by the presence of lymphoplasmacytic lymphoma in the bone marrow or other organs, a monoclonal IgM paraproteinemia and the recurrent MYD88 L265P somatic mutation.
|
31591468 |
2019 |
Waldenstrom Macroglobulinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
High frequencies of the hotspot <i>MYD88</i>(L265P) mutation are observed in extranodal diffuse large B-cell lymphoma and Waldenström macroglobulinemia, thereby demonstrating this mutation's potential as a disease marker.
|
31699794 |
2019 |
Waldenstrom Macroglobulinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The diagnosis of Waldenström Macroglobulinaemia (WM)/lymphoplasmacytic lymphoma (LPL) remains one of exclusion because other B-cell lymphoproliferative disorders (B-LPD), such as marginal zone lymphoma (MZL), can fulfil similar criteria, including MYD88 L265P mutation.
|
30198568 |
2019 |
Waldenstrom Macroglobulinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, in this small case series we showed that MYD88 L265P mutation analysis could serve as a useful adjunct in distinguishing benign from lymphomatous PE in patients with LPL.
|
31556196 |
2019 |
Waldenstrom Macroglobulinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Nine of these samples tested positive for MYD88 p.(L265P) (8 LPL and 1 PCNSL).
|
29210102 |
2018 |
Waldenstrom Macroglobulinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The MYD88 L265P mutation is present in nearly 90% of patients with Waldenström macroglobulinemia.
|
30190015 |
2018 |
Waldenstrom Macroglobulinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Few cancers such as WM</span> have a single amino acid substitution in one gene like MYD88 L265P that occurs in ∼90% of cases, making WM </span>paradigmatic for study of a single causative mutation in oncogenesis.
|
29703722 |
2018 |
Waldenstrom Macroglobulinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The MYD88 missense mutation c.794T>C, p.Leu265Pro, is found in patients with Waldenstörm's macroglobulinemia and lymphoma.
|
28042684 |
2017 |
Waldenstrom Macroglobulinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Patients with the mutated MYD88 L265P genotype with WM and MZL were compared.
|
28280994 |
2017 |
Waldenstrom Macroglobulinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
MYD88 L265P mutation in cutaneous involvement by Waldenström macroglobulinemia.
|
28370087 |
2017 |
Waldenstrom Macroglobulinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The revised 2016 World Health Organization classification includes the MYD88 L265P mutation, which is seen in >90% of cases, within the diagnostic criteria for WM.
|
28076910 |
2017 |
Waldenstrom Macroglobulinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present study demonstrates that MYD-88 L265P mutation may represent the only sensitive marker for the differentiation of CBL-MZ from probable WM.
|
27734522 |
2017 |
Waldenstrom Macroglobulinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The detection in the cerebrospinal fluid of patients with Bing-Neel syndrome of the MYD88 (L265P) somatic mutation, which is highly recurrent in Waldenström's Macroglobulinemia, proved useful for the diagnosis and monitoring of central nervous system involvement.
|
29181138 |
2017 |
Waldenstrom Macroglobulinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The recent surge in next generation sequencing (NGS) technology has shed more light on the genetic landscape of SBCLs through characterization of numerous driver mutations including SF3B1 and NOTCH1 in CLL, ATM and CCND1 in MCL, KMT2D and EPHA7 in FL, MYD88 (L265P) in LPL, KLF2 and NOTCH2 in splenic MZL (SMZL) and BRAF (V600E) in HCL.
|
27121112 |
2016 |
Waldenstrom Macroglobulinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Whole genome sequencing has identified somatic mutations in the CXCR4 gene in ∼29% of WM cases with MYD88(L265P).
|
27268124 |
2016 |
Waldenstrom Macroglobulinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The findings show that CXCR4(WHIM) mutations are more common in WM than previously revealed, and are primarily subclonal, supporting their acquisition after MYD88(L265P) in WM oncogenesis.
|
26659815 |
2016 |
Waldenstrom Macroglobulinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Identical clonal origin was confirmed by PCR for 21 LPL/WM cases and MYD88 L265P was detected in both B-cell and plasma cell fractions.
|
27890075 |
2016 |
Waldenstrom Macroglobulinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Whole-genome sequencing has revealed MYD88 L265P and CXCR4 mutations (CXCR4(mut)) as the most prevalent somatic mutations in Waldenström macroglobulinemia.
|
26490317 |
2016 |
Waldenstrom Macroglobulinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Non-IgM LPLs are a clinically and pathologically heterogeneous group and often harbor MYD88 L265P mutation, albeit at a lower rate than classic WM.
|
27329639 |
2016 |
Waldenstrom Macroglobulinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Successful treatment of refractory cold hemagglutinemia in MYD88 L265P mutation-negative Waldenström's macroglobulinemia with bortezomib.
|
25794560 |
2015 |
Waldenstrom Macroglobulinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The MYD88 L265P mutation appears to be frequently present in circulating cells in patients with WM, and MGUS, and these cells are amenable to immortalization by EBV.
|
26352266 |
2015 |
Waldenstrom Macroglobulinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
MYD88(L265P) and CXCR4(WHIM) mutations are highly prevalent in Waldenström's macroglobulinemia.
|
25853747 |
2015 |
Waldenstrom Macroglobulinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of our study was to establish an unlabeled probe genotyping approach for rapid detection of the MYD88 L265P mutation in the differential diagnosis of Waldenstrӧm macroglobulinemia patients.
|
25462104 |
2015 |