Carcinogenesis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results suggest that SNP rs4444235 at 14q22.2 and SNP rs2423279 at 20p12.3 may interact with regular exercise and aspirin use in colorectal carcinogenesis.
|
31849324 |
2019 |
Adenoma of large intestine
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings demonstrated that BMP4-rs4444235 is a risk factor associated with increased CRC and CRA susceptibility, but these associations vary in different ethnic populations.
|
25647270 |
2015 |
Malignant neoplasm of esophagus
|
|
0.010 |
GeneticVariation
|
BEFREE |
The minor alleles of rs1321311 and rs4444235 were associated with a 1.53-fold (95%CI: 1.15-2.06; P = 0.004) and 1.28-fold (95%CI: 1.03-1.60; P = 0.028) increased risk of esophageal cancer in the allelic model analysis, respectively.
|
26078566 |
2015 |
Esophageal Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
The minor alleles of rs1321311 and rs4444235 were associated with a 1.53-fold (95%CI: 1.15-2.06; P = 0.004) and 1.28-fold (95%CI: 1.03-1.60; P = 0.028) increased risk of esophageal cancer in the allelic model analysis, respectively.
|
26078566 |
2015 |
Esophageal carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The minor alleles of rs1321311 and rs4444235 were associated with a 1.53-fold (95%CI: 1.15-2.06; P = 0.004) and 1.28-fold (95%CI: 1.03-1.60; P = 0.028) increased risk of esophageal cancer in the allelic model analysis, respectively.
|
26078566 |
2015 |
Tumor Progression
|
|
0.010 |
GeneticVariation
|
BEFREE |
LOH analysis suggested that the three CRC risk variants, rs12657484, rs3802842, and rs4444235, exhibited somatic allele-specific imbalance and might be critical during neoplastic progression.
|
24968322 |
2014 |
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
A total of 927 MMR gene mutation carriers (360 MLH1, 442 MSH2, 85 MSH6 and 40 PMS2) from 315 families enrolled in the Colon Cancer Family Registry, were genotyped for the single nucleotide polymorphisms (SNPs): rs16892766 (8q23.3), rs6983267 (8q24.21), rs719725 (9p24), rs10795668 (10p14), rs3802842 (11q23.1), rs4444235 (14q22.2), rs4779584 (15q13.3), rs9929218 (16q22.1), rs4939827 (18q21.1), rs10411210 (19q13.1) and rs961253 (20p12.3).
|
23434150 |
2013 |
Hereditary Nonpolyposis Colorectal Cancer
|
|
0.010 |
GeneticVariation
|
BEFREE |
Regarding early-onset cases, 14q22 (rs4444235), 11q23 (rs3802842) and 20p12 (rs961253) variants were more associated with family history of CRC or tumors of the Lynch syndrome spectrum excluding CRC.
|
22235025 |
2012 |
Colonic Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Several loci showed statistically significant associations with specific phenotypes notably rs6691170 and rs3802842 associated with microsatellite stable rectal disease; rs4779584, rs961253 and rs4813802 associated with microsatellite stable colonic disease and rs4444235 and rs4925386 with microsatellite instability colonic disease.
|
22045029 |
2012 |
Lynch Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Regarding early-onset cases, 14q22 (rs4444235), 11q23 (rs3802842) and 20p12 (rs961253) variants were more associated with family history of CRC or tumors of the Lynch syndrome spectrum excluding CRC.
|
22235025 |
2012 |
Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
We observed an association between the low colorectal cancer risk allele (A) for rs10795668 at 10p14 and increased expression of ATP5C1 (q = 0.024) and between the colorectal cancer high risk allele (C) for rs4444235 at 14q22.2 and increased expression of DLGAP5 (q = 0.041), both in tumor samples.
|
22363440 |
2012 |
Alcohol or Other Drugs use
|
|
0.010 |
GeneticVariation
|
BEFREE |
We used meta-analysis of an efficient empirical-Bayes estimator to detect potential multiplicative interactions between each of the SNPs [rs16892766 at 8q23.3 (EIF3H/UTP23), rs6983267 at 8q24 (MYC), rs10795668 at 10p14 (FLJ3802842), rs3802842 at 11q23 (LOC120376), rs4444235 at 14q22.2 (BMP4), rs4779584 at 15q13 (GREM1), rs9929218 at 16q22.1 (CDH1), rs4939827 at 18q21 (SMAD7), rs10411210 at 19q13.1 (RHPN2), and rs961253 at 20p12.3 (BMP2)] and select major CRC risk factors (sex, body mass index, height, smoking status, aspirin/nonsteroidal anti-inflammatory drug use, alcohol use, and dietary intake of calcium, folate, red meat, processed meat, vegetables, fruit, and fiber).
|
22367214 |
2012 |
Malignant neoplasm of colon and/or rectum
|
|
0.050 |
GeneticVariation
|
BEFREE |
The SNP rs4444235 at 14q22.2 interacted with regular exercise in colorectal cancer (p<sub>case-only</sub> = 2.4 × 10<sup>- 3</sup>, p<sub>case-control</sub> = 1.5 × 10<sup>- 3</sup>).
|
31849324 |
2019 |
Malignant neoplasm of colon and/or rectum
|
|
0.050 |
GeneticVariation
|
BEFREE |
Genome-wide association studies have identified rs4444235 at BMP4 as a new colorectal cancer (CRC) and colorectal adenoma (CRA) susceptibility locus in populations of European descent.
|
25647270 |
2015 |
Malignant neoplasm of colon and/or rectum
|
|
0.050 |
GeneticVariation
|
BEFREE |
The common variant rs4444235 near BMP4 confers genetic susceptibility of colorectal cancer: an updated meta-analysis based on a comprehensive statistical strategy.
|
24932582 |
2014 |
Malignant neoplasm of colon and/or rectum
|
|
0.050 |
GeneticVariation
|
BEFREE |
BMP4 rs4444235 is a candidate susceptibility allele that has been associated with an increased risk of colore</span>ctal cancer.
|
22170598 |
2012 |
Malignant neoplasm of colon and/or rectum
|
|
0.050 |
GeneticVariation
|
BEFREE |
We observed an association between the low colorectal cancer risk allele (A) for rs10795668 at 10p14 and increased expression of ATP5C1 (q = 0.024) and between the colorectal cancer high risk allele (C) for rs4444235 at 14q22.2 and increased expression of DLGAP5 (q = 0.041), both in tumor samples.
|
22363440 |
2012 |
COLORECTAL CANCER, SUSCEPTIBILITY TO, 10
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Novel Common Genetic Susceptibility Loci for Colorectal Cancer.
|
29917119 |
2019 |
COLORECTAL CANCER, SUSCEPTIBILITY TO, 1
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Novel Common Genetic Susceptibility Loci for Colorectal Cancer.
|
29917119 |
2019 |
COLORECTAL CANCER, SUSCEPTIBILITY TO, 3
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Novel Common Genetic Susceptibility Loci for Colorectal Cancer.
|
29917119 |
2019 |
Adenocarcinoma of large intestine
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Novel Common Genetic Susceptibility Loci for Colorectal Cancer.
|
29917119 |
2019 |
Malignant neoplasm of large intestine
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Novel Common Genetic Susceptibility Loci for Colorectal Cancer.
|
29917119 |
2019 |
COLORECTAL CANCER, SUSCEPTIBILITY TO, 12
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Novel Common Genetic Susceptibility Loci for Colorectal Cancer.
|
29917119 |
2019 |
Colorectal Neoplasms
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Novel Common Genetic Susceptibility Loci for Colorectal Cancer.
|
29917119 |
2019 |
COLORECTAL CANCER, SUSCEPTIBILITY TO, 10
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of colorectal cancer identifies six new susceptibility loci.
|
26151821 |
2015 |