|
Cannabis use
|
|
0.100 |
GeneticVariation
|
BEFREE |
A meta-analysis was performed using papers investigating the interaction between cannabis use and catechol-O-methyl transferase (COMT) polymorphism Val158Met (COMTVal158Met).
|
29444152 |
2018 |
|
Cannabis use
|
|
0.100 |
GeneticVariation
|
BEFREE |
The relationship between age at psychosis onset and COMT Val158Met and BDNF Val66Met polymorphisms with early cannabis use as well as those factors associated with early cannabis use were investigated.
|
28142064 |
2017 |
|
Cannabis use
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data are indicative of the need to further investigate the association between the <i>COMT</i> rs4680 variant and AoP in the context of adolescent cannabis use.
|
29201551 |
2017 |
|
Cannabis use
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggest that the COMT Val(158)Met polymorphism moderates the effect of regular cannabis use on severity of subclinical psychotic symptoms.
|
27052366 |
2016 |
|
Cannabis use
|
|
0.100 |
GeneticVariation
|
BEFREE |
The findings from this study confirm the association between COMT Val158 Met polymorphism and pre-morbid cannabis use in causing schizophrenia.
|
25600541 |
2015 |
|
Cannabis use
|
|
0.100 |
GeneticVariation
|
BEFREE |
Psychotic experiences (PEs), childhood abuse, cannabis use and COMT Val158Met genotypes were assessed in 533 individuals from the general population.
|
23445265 |
2014 |
|
Cannabis use
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, the COMT Val(158)Met polymorphism may constitute a genetic risk factor for psychotic symptoms in the context of combined exposure to childhood maltreatment and cannabis use.
|
23954148 |
2013 |
|
Cannabis use
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found that: (i) daily cannabis use is not associated with executive function deficits; and (ii) COMT val158met and 5-HTTLPR polymorphisms moderate the link between cannabis use and executive performance.
|
23449176 |
2013 |
|
Cannabis use
|
|
0.100 |
GeneticVariation
|
BEFREE |
Schizophrenic subjects homozygous for the Met allele at rs4680 doubled the probability of lifetime prevalence of cannabis use in comparison to Val homozygous (Mantel-Haenszel OR=2.07, 95% CI: 1.27-3.26, P=0.0031, in the combined sample).
|
21310591 |
2011 |
|
Cannabis use
|
|
0.100 |
GeneticVariation
|
BEFREE |
Third, an interaction between Val158Met genotypes and cannabis use was observed specifically on age at emergence of psychotic disorders, with Val/Val genotype carriers showing an earlier age at onset than Met carriers.
|
21231925 |
2011 |
|
Cannabis use
|
|
0.100 |
GeneticVariation
|
BEFREE |
Logistic regression and generalized estimating equations' analyses were used to examine the role of adolescent-onset cannabis use (< or =15 years of age) on CIP risk, both controlling for previously implicated CIP risk factors and familial relationships, and considering potential interactions with COMT Val158Met genotype.
|
19944543 |
2010 |
|
Cannabis use
|
|
0.100 |
GeneticVariation
|
BEFREE |
Catechol-O-Methyltransferase (COMT) Val158Met variations and cannabis use in first-episode non-affective psychosis: clinical-onset implications.
|
20493536 |
2010 |