|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
TP53 Arg72Pro (rs1042522 C > G) and miR-34b/c rs4938723 (T > C) polymorphisms have been known to modify cancer susceptibility.
|
31325764 |
2019 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
In summary, the findings of this meta-analysis indicated that the miR-34b/c rs4938723 polymorphism might be associated with some cancer development.
|
30203457 |
2019 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Furthermore, studies with larger sample sizes and including gene-gene or gene-environment interactions should be carried out to elucidate the role of rs4938723 polymorphism in cancer risk.
|
30286050 |
2018 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association studies between miR-34b/c rs4938723 polymorphism and cancer risk showed conflicting results.
|
27983526 |
2017 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results indicate a significant association between the rs4938723 polymorphism and cancer risk in the overdominant model (P heterogeneity = 0.018, OR = 1.093, and 95% CI = 1.015-1.177 for CT vs. CC/TT).
|
28415817 |
2017 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The impact of Pri-miR-34b/c rs4938723 variant on development of various cancers is still controversial.
|
27886674 |
2016 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
A polymorphism rs4938723 (T > C) within the promoter region of pri-miR-34b/c has been found to not only affect the expression of mature miR-34b/c but also contribute to the susceptibility to several cancer types.
|
26380954 |
2016 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
After stratifying by ethnicity and cancer type, genotype CT of rs4938723 was significantly association with an increased cancer risk in Asian population (P(h)=0.187, OR=1.10, 95%CI=1.01-1.20), allele C and genotype CT were significantly positive associated with hepatocellular cancer (P(h)=0.113, OR=1.11, 95%CI=1.01-1.23 for C vs. T; P(h)=0.121, OR=1.19, 95%CI=1.03-1.37 for CT vs. TT), but rs4938723 was negative associated with risk of colorectal cancer (P(h)=0.342, OR=0.66, 95%CI=0.47-0.92 for CC vs. TT; P(h)=0.519, OR=0.67, 95%CI=0.49-0.93 for CC vs. CT/TT; P(h)=0.443, OR=0.71, 95%CI=0.51-0.99 for CC/TT vs. CT).
|
25475831 |
2015 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
MiR-34b/c rs4938723 Polymorphism Significantly Decreases the Risk of Digestive Tract Cancer: Meta-analysis.
|
26320502 |
2015 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Overall, the current study suggests that the miR-34b/c rs4938723 polymorphism may be associated with the risk of cancers, including nasopharyngeal cancer, osteosarcoma, and renal cell cancer, and to some extent this polymorphism is closely related to cancer susceptibility in Asians.
|
25326793 |
2014 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thus our meta-analysis suggests that the pri-miR-34b/c rs4938723 TC heterozygote contributes to increased overall cancer risks, as well as shown in digestive tract cancers, in hepatocellular cancer, in Asian population and in the large-sample subgroup.
|
25201061 |
2014 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
In subgroup analysis of ethnicity, pri-miR-34b/c rs4938723 polymorphism was significantly associated with an increased cancer susceptibility for Asian population in heterozygous model (TC vs. TT: OR = 1.169, 95%CI 1.031-1.326, P = 0.015) and dominant model (CC + TC vs. TT: OR = 1.185, 95%CI 1.017-1.382, P = 0.030), whereas no significant association for Caucasian population was observed in any genetic models.
|
25190019 |
2014 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
A single nucleotide polymorphism T > C (rs4938723) located within the CpG island in the promoter region of pri-miR-34b/c may affect its expression and has been suggested to influence cancer risk.
|
24503183 |
2014 |