rs5743708, TLR2

N. diseases: 98
Disease: Rheumatic Heart Disease ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Rheumatic Heart Disease
CUI: C0035439
Disease: Rheumatic Heart Disease
0.030 GeneticVariation BEFREE Although Arg753Gln polymorphism of the TLR2 gene was considered to be related to acute rheumatic fever susceptibility in child, two groups have identified that there were no relations between this Arg753Gln polymorphism and rheumatic heart disease susceptibility. 25487598 2015
Rheumatic Heart Disease
CUI: C0035439
Disease: Rheumatic Heart Disease
0.030 GeneticVariation BEFREE In conclusion, TLR2 gene Arg753Gln polymorphism is not associated with BD nor with RHD; and a duplicated region of the TLR2 exon 3 located 23-kb upstream of the polymorphic region may explain contradictory association findings described so far. 19693643 2009
Rheumatic Heart Disease
CUI: C0035439
Disease: Rheumatic Heart Disease
0.030 GeneticVariation BEFREE The lack of genetic association of the Toll-like receptor 2 (TLR2) Arg753Gln and Arg677Trp polymorphisms with rheumatic heart disease. 17096074 2007