rs58542926, TM6SF2

N. diseases: 42
Disease: Obesity ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Obesity
CUI: C0028754
Disease: Obesity
0.030 GeneticVariation BEFREE There was no significant difference in the proportions of patients with rs738409 C>G in PNPLA3, but a significantly greater proportion of patients with lean NAFLD carried rs58542926 C>T in TM6SF2 (4%) than obese or overweight individuals with NAFLD (0.3%; P = .001). 28554682 2017
Obesity
CUI: C0028754
Disease: Obesity
0.030 GeneticVariation BEFREE Although the TMS6SF2 E167K variant predisposes the obese children to non-alcoholic fatty liver disease, there is an association between this variant and lower levels of cardiovascular risk factors. 25893821 2016
Obesity
CUI: C0028754
Disease: Obesity
0.030 GeneticVariation BEFREE In conclusion, PNPLA3 I148M, but not TM6SF2 E167K, affects de novo NAFLD occurrence with a prominent interaction with obesity. 26379412 2015