rs58542926, TM6SF2

N. diseases: 42
Disease: Cirrhosis ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Cirrhosis
CUI: C1623038
Disease: Cirrhosis
0.030 GeneticVariation BEFREE Carriage of TM6SF2 rs58542926 is an additional risk factor for the development of HCC in people with alcohol-related cirrhosis. 29535416 2018
Cirrhosis
CUI: C1623038
Disease: Cirrhosis
0.030 GeneticVariation BEFREE In conclusion, the TM6SF2 E167K variant promotes the development of steatosis, fibrosis and cirrhosis in patients with chronic hepatitis C. Conversely, this variant reduces circulating atherogenic lipid fractions. 28839198 2017
Cirrhosis
CUI: C1623038
Disease: Cirrhosis
0.030 GeneticVariation BEFREE After further conditioning for steatosis and necroinflammation, the E167K variant remained associated with cirrhosis (OR, 3.15; 95% CI: 1.60-5.99; P < 0.001). 25820484 2015