Mood Disorders
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0.100 |
GeneticVariation
|
BEFREE |
This study has examined the association between the BDNF gene Val66Met polymorphism and mood disorders, age of onset and suicidal behavior in a Chinese sample population.
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14673216 |
2003 |
Mood Disorders
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|
0.100 |
GeneticVariation
|
BEFREE |
The combination of disadvantageous allelic expression of rs6295 and rs6265 may result in a 5-HT<sub>1A</sub> receptor profile comparable to affective disorders as increased 5-HT<sub>1A</sub> receptor binding is a well published phenotype of depression.
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30664620 |
2019 |
Mood Disorders
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|
0.100 |
GeneticVariation
|
BEFREE |
Further, 2 genetic polymorphisms: the 5-HTTLPR and the brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms were not directly associated with familial risk for affective disorder and did not predict illness onset.
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27697135 |
2016 |
Mood Disorders
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0.100 |
GeneticVariation
|
BEFREE |
Individuals at high risk of affective disorders and who are carriers of the met allele of the Val66Met polymorphism may present with an enhanced stress response.
|
19473771 |
2009 |
Mood Disorders
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|
0.100 |
GeneticVariation
|
BEFREE |
The brain-derived neurotrophic factor (BDNF) Val(66) Met allelic variation is linked to both the occurrence of mood disorders and antidepressant response.
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22225729 |
2012 |
Mood Disorders
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0.100 |
GeneticVariation
|
BEFREE |
BDNF gene: functional Val66Met polymorphism in mood disorders and schizophrenia.
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19018714 |
2008 |
Mood Disorders
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|
0.100 |
GeneticVariation
|
BEFREE |
Preliminary evidence suggests that BDNF (brain derived neurotrophic factor) rs6265 genetic polymorphism, BDNF gene promotor methylation and BDNF serum levels might play an important role in the pathogenesis of affective disorders.
|
30929061 |
2020 |
Mood Disorders
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|
0.100 |
GeneticVariation
|
BEFREE |
Four of the most consistently replicated variants associated with mood disorder occur in genes important for synaptic function: ANK3 (rs10994336), BDNF (rs6265), CACNA1C (rs1006737), and DGKH (rs1170191).
|
24944871 |
2014 |
Mood Disorders
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0.100 |
GeneticVariation
|
BEFREE |
BDNF polymorphism, val66met, has also been implicated in mood disorders.
|
24398043 |
2014 |
Mood Disorders
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|
0.100 |
GeneticVariation
|
BEFREE |
BDNF variation and mood disorders: a novel functional promoter polymorphism and Val66Met are associated with anxiety but have opposing effects.
|
15770238 |
2005 |
Mood Disorders
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|
0.100 |
GeneticVariation
|
BEFREE |
Individuals with schizoaffective disorder and other affective disorders were significantly more likely to carry two copies of the most common BDNF haplotype (containing the valine allele of the Val66Met polymorphism) compared with healthy volunteers.
|
19336781 |
2009 |
Mood Disorders
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|
0.100 |
GeneticVariation
|
BEFREE |
Further investigations in larger samples are needed to clarify the usefulness of 5-HTTLPR and BDNF Val66Met genotyping in the optimization of non-pharmacological treatments in mood disorders.
|
18450378 |
2008 |
Mood Disorders
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|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met polymorphism has been associated with sensitivity to stress and affective disorders.
|
28926000 |
2017 |
Mood Disorders
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|
0.100 |
GeneticVariation
|
BEFREE |
However, previous genetic association studies of Val66Met polymorphism in the clinical risk of mood disorders have been complicated, possibly due to phenotypic diversity, underpowered statistical association or ancestry-specific effects.
|
27236043 |
2016 |
Mood Disorders
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|
0.100 |
GeneticVariation
|
BEFREE |
Analyzing the Effect of V66M Mutation in BDNF in Causing Mood Disorders: A Computational Approach.
|
28427565 |
2017 |
Mood Disorders
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0.100 |
GeneticVariation
|
BEFREE |
This variant and two previously reported BDNF SNPs (C270T and Val66Met) were genotyped in 295 patients with AD, 108 with AFDs, 96 with posttraumatic stress disorder (PTSD), 84 with schizophrenia, 327 with alcohol and/or drug dependence, and 250 normal control subjects.
|
16649215 |
2006 |
Mood Disorders
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|
0.100 |
GeneticVariation
|
BEFREE |
Studies have indicated that a functional polymorphism (Val66Met) in a brain-derived neurotrophic factor (BDNF) gene can influences human cognitive functions and mood disorders.
|
23823988 |
2013 |
Mood Disorders
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0.100 |
GeneticVariation
|
BEFREE |
The impact of BDNF Val66Met polymorphism on cognition in Bipolar Disorder: A review: Special Section on "Translational and Neuroscience Studies in Affective Disorders" Section Editor, Maria Nobile MD, PhD. This Section of JAD focuses on the relevance of translational and neuroscience studies in providing a better understanding of the neural basis of affective disorders. The main aim is to briefly summaries relevant research findings in clinical neuroscience with particular regards to specific innovative topics in mood and anxiety disorders.
|
30078664 |
2019 |
Mood Disorders
|
|
0.100 |
GeneticVariation
|
BEFREE |
Brain-Derived Neurotrophic Factor (BDNF) Val66Met polymorphism has been associated with increased susceptibility to develop mood disorders and recently it has been also linked with cardiovascular disease (CVD).
|
30347685 |
2018 |
Mood Disorders
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|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate whether BDNF alone or in interaction with the BDNF Val66Met polymorphism predict onset of affective disorder in healthy individuals at heritable risk for affective disorder.
|
24112874 |
2014 |
Mood Disorders
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|
0.100 |
GeneticVariation
|
BEFREE |
In the present study, we evaluated the impact of the BDNF Val66Met polymorphism on individual differences in personality traits in a sample of healthy volunteers in relation to other common gene variants thought to be involved in the pathophysiology of affective disorders, such as the serotonin transporter promoter polymorphism (5-HTTLPR) and a variable number of tandem repeat polymorphism of the dopamine transporter gene (DAT VNTR).
|
17392738 |
2007 |
Mood Disorders
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|
0.100 |
GeneticVariation
|
BEFREE |
A polymorphism of the human Brain Derived Neurotrophic Factor (BDNF) gene that produces a valine-to-methionine substitution at codon 66 (Val66Met) is linked to adult anxiety and mood disorders, possibly through effects on brain circuitry function.
|
19931400 |
2010 |
Mood Disorders
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|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met polymorphism may confer risk for mood disorders in females through effects on amygdala-cortical connectivity during adolescence, coinciding with a period in the lifespan when onset of depression often occurs, more commonly in females.
|
28387866 |
2018 |
Mood Disorders
|
|
0.100 |
GeneticVariation
|
BEFREE |
In MDD, however, the effect of the val66met polymorphism is not detectable, possibly due to a ceiling effect of over-expression of 5-HT(1A) receptors in mood disorders.
|
24607934 |
2014 |
Mood Disorders
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|
0.100 |
GeneticVariation
|
BEFREE |
The effect of the Val66Met polymorphism on synaptic transmission and plasticity in the IL-mPFC represents a mechanism to account for this impact of SNP on affective disorders and cognitive dysfunction.
|
22396415 |
2012 |