|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Val66Met polymorphism of the BDNF gene may be associated with cognitive performance on the WCST in bipolar mood disorder but not in schizophrenia.
|
16472361 |
2006 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
DNA samples from the Treatment of Early Age Mania (TEAM) and Mayo Clinic Bipolar Disorder Biobank were investigated for association of rs6265 with early-onset bipolar disorder.
|
26528762 |
2015 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Effects of the brain-derived neurotrophic growth factor val66met variation on hippocampus morphology in bipolar disorder.
|
18704093 |
2009 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between brain-derived neurotrophic factor genetic polymorphism Val66Met and susceptibility to bipolar disorder: a meta-analysis.
|
25539739 |
2014 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our study also adds to the body of evidence associating the functional Val66Met polymorphism of BDNF with BD.
|
22085476 |
2012 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
BDNF rs6265 was associated with St in the BD group (p = 0.017).
|
30041166 |
2017 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
BDNF Val66Met polymorphism and bipolar disorder in European populations: A risk association in case-control, family-based and GWAS studies.
|
27236043 |
2016 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Few genetic studies exploring the impact of Val66Met on cognition in BD.
|
30078664 |
2019 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further studies are needed to evaluate the genetic association between the val66met allele and the BD-PTSD population, along with central/peripheral BDNF levels and epigenetic patterns of BDNF gene regulation within these patients.
|
21931317 |
2012 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Lithium response and Val66Met polymorphism of the brain-derived neurotrophic factor gene in Japanese patients with bipolar disorder.
|
16538178 |
2006 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Haplotype analysis of marker combination rs988748-(GT)n-rs6265 produced nominally significant associations for all investigated phenotypes (global p values: MDD p = .00006, BPAD p = .0057, schizophrenia p = .016).
|
16005437 |
2005 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We performed a family-based association study and ETDT analyses of the Val66Met polymorphism in 312 BD nuclear families, and compared allele-specific mRNA levels in both post-mortem brain samples and B lymphoblasts from BD patients and controls.
|
18606495 |
2008 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Val66Met polymorphism and serum brain-derived neurotrophic factor in bipolar disorder: an open-label trial.
|
23957567 |
2014 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here we investigated a two hit gene environment model in relation to functional genomic factors (BDNF mRNA), and volume of hippocampal subfields in schizophrenia spectrum and bipolar disorders, focusing on both an environmental (childhood trauma) and genetic risk factor (BDNF val66met).
|
25246365 |
2014 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The val66met single-nucleotide polymorphism (SNP) showed significant (P = 0.005) association for valine (allele G) with schizophrenia but not bipolar disorder.
|
15630410 |
2005 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of the present study was to examine the interplay between the BDNF Val(66)Met polymorphism and stressful life events (SLEs) in bipolar disorder.
|
20172611 |
2010 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Meta-analysis reveals no association of the Val66Met polymorphism of brain-derived neurotrophic factor with either schizophrenia or bipolar disorder.
|
17417060 |
2007 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our study suggests that the markers examined thus far in COMT and SLC6A4 are not associated with pediatric bipolar disorder and that if the val66met marker in BDNF is associated with pediatric bipolar disorder the magnitude of the association is much smaller than first reported.
|
19193231 |
2009 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Changes in gyrification over 4 years in bipolar disorder and their association with the brain-derived neurotrophic factor valine(66) methionine variant.
|
19167700 |
2009 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese patients with bipolar disorder and schizophrenia.
|
24468644 |
2014 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the neurochemistry of the left dorsolateral prefrontal cortex of bipolar disorder and healthy participants in relation to the brain-derived neurotrophic factor val66met polymorphism using H-magnetic resonance spectroscopy.
|
17885603 |
2007 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although the present study has some limitations, the results indicate a lack of association between the Val66Met polymorphism and bipolar disorder</span>.
|
25041243 |
2015 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF val66met polymorphism is a potential vulnerability factor for cognitive impairment in BD.
|
24862657 |
2014 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We examined the association between the BDNF Val66Met and DRD3 Ser9Gly polymorphisms with two subtypes of bipolar disorder: bipolar-I and -II.
|
22877924 |
2012 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Variation at the Val66Met polymorphism of BDNF does not play a major role in influencing susceptibility to bipolar disorder as a whole, but is associated with susceptibility to the rapid-cycling subset of the disorder.
|
16388065 |
2006 |