rs6277, DRD2

N. diseases: 36
Disease: Nicotine Dependence ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Nicotine Dependence
CUI: C0028043
Disease: Nicotine Dependence
0.020 GeneticVariation BEFREE Patients with chronic addiction exhibit reduced dopamine D2 receptor (DRD2) availability in the striatum, and the <i>DRD2</i> TaqIA (rs1800497) and C957T (rs6277) genetic polymorphisms have previously been linked to individual differences in striatal dopamine metabolism and clinical risk for alcohol and nicotine dependence. 28507526 2017
Nicotine Dependence
CUI: C0028043
Disease: Nicotine Dependence
0.020 GeneticVariation BEFREE Our findings suggest that the DRD2 C957T polymorphism and the ANKK1 TaqIA polymorphism are key contributors to the genetic susceptibility to nicotine dependence. 22382052 2012