|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
This work has implications for a number of psychiatric conditions in which dopamine signaling and variation in C957T status have been implicated, including schizophrenia and substance use disorders.
|
28398340 |
2017 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Remarkably, alleles of <i>COMT</i> rs165774 (G), <i>DRD2</i> rs6277 (T), and <i>DRD3</i> rs6280 (C) were associated with raised predisposition to schizophrenia (all <i>P</i><0.001).
|
29255361 |
2017 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The DRD2 C957T is also associated with schizophrenia, with the C allele being the risk allele.
|
29945153 |
2017 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our meta-analysis suggests an association of the DRD2 gene and the risk for schizophrenia, given that TaqI and C957T polymorphisms presented a protective effect against schizophrenia, and in the sub-analyses the C957T variant increased the risk for this disorder in the Chinese population.
|
27829443 |
2016 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In a cross-sectional study, we examined 2 dopamine D2 receptor (DRD2) single-nucleotide polymorphisms (SNPs) previously associated with schizophrenia (C939 T, rs6275 and C957 T, rs6277) along with fasting blood glucose and body mass index (BMI) in 207 antipsychotic-treated patients with schizophrenia.
|
27254804 |
2016 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our study suggested that C957T of DRD2 gene polymorphism is likely to be a risk factor for schizophrenia, especially in Caucasian.
|
25240594 |
2014 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We have previously identified a genetic variant in DRD2, rs6277 to be strongly implicated in schizophrenia susceptibility.
|
21861710 |
2012 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data indicated a nominally significant association of rs6277 with SZ, with T-allele being the risk allele (OR=1.58, 95%CI=1.03-2.43, P=0.034).
|
19913597 |
2010 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Of the 183 SNPs successfully genotyped, only 1 SNP, rs6277 (C957T) in the DRD2 gene (P=0.0010, odds ratio=1.76), was considered to be significantly associated with schizophrenia after the replication study using independent sample sets.
|
19158809 |
2009 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Though no association was found between the TaqIA polymorphism and schizophrenia, a haplotype-wise analysis revealed a lower frequency of the T-C (C957T-TaqIA) haplotype in patients (p=0.02).
|
18255274 |
2008 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We propose that an interaction of the DRD2 C957T and COMT Val158Met may be involved in the generation of some working memory deficits in schizophrenia.
|
17113268 |
2007 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
C957T DRD2 polymorphism is associated with schizophrenia in Spanish patients.
|
17087792 |
2006 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results are in agreement with an earlier association study suggesting that the C957T C-allele plays a role in the genetic vulnerability for schizophrenia and support the involvement of the DRD2 gene in schizophrenia pathogenesis.
|
16973280 |
2006 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C957T shows a population attributable risk for schizophrenia of 24% and an attributable risk in those with schizophrenia of 42%.
|
15567074 |
2005 |