rs671, ALDH2

N. diseases: 116
Disease: Osteoporosis ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Osteoporosis
CUI: C0029456
Disease: Osteoporosis
0.020 GeneticVariation BEFREE Association of rs671 with hip fracture and osteoporosis was significant even after adjustment for age and body mass index. 28348376 2017
Osteoporosis
CUI: C0029456
Disease: Osteoporosis
0.020 GeneticVariation BEFREE Here we show that a dominant-negative form of aldehyde dehydrogenase 2 (ALDH2) protein, ALDH2*2, which is produced by a single nucleotide polymorphism (rs671), promotes osteoporosis due to impaired osteoblastogenesis. 22508505 2012